Complex formation equilibria of Cu2+ and Zn2+ with Irbesartan and Losartan

Show simple item record Lachowicz, JI en Nurchi, VM en Crisponi, G en Jaraquemada-Pelaez, MDG en Caltagirone, C en Peana, M en Zoroddu, MA en Szewczuk, Z en Cooper, Garth en 2017-03-03T04:55:45Z en 2016-11-07 en 2017-01-15 en
dc.identifier.citation European Journal of Pharmaceutical Sciences, 15 January 2017, 97, 158 - 169 en
dc.identifier.issn 0928-0987 en
dc.identifier.uri en
dc.description.abstract We conducted a thorough study of Cu2 + complex formation equilibria with Irbesartan and Losartan, the two primary drugs for the cure of cardiovascular diseases, with the aim of recognising if these drugs could exert a chelating action towards Cu2 +. We used different complementary techniques to gain a clear picture of the involved protonation and complexation equilibria. The low solubility in water of the ligands and of the formed metal complexes prevented the use of water as solvent, so we had to perform the measurements in mixed methanol-water solvents. Further, we studied the related equilibria with Zn2 + for evaluating a potential interference of this essential metal ion, largely present in biological fluids. Our study provided a strong evaluation of the formed complexes and of the relative stability constants. The binding of both metal ions takes place through the tetrazole moiety except for the Zn2 +-Irbesartan system. In this last case, NMR measurements gave evidence of a tautomeric equilibrium involving the imidazole ring and the aliphatic chain. The estimated complexation model, and the related stability constants, allowed a speciation study in human plasma, based on a number of simplifying assumptions, which remarked that both drugs, Losartan and Irbesartan, could exert a chelating action, scavenging non-negligible amounts of Cu2 + from the organism. en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries European Journal of Pharmaceutical Sciences en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Complex formation equilibria of Cu2+ and Zn2+ with Irbesartan and Losartan en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ejps.2016.11.010 en
pubs.begin-page 158 en
pubs.volume 97 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 27838251 en en
pubs.end-page 169 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 546557 en Science en Biological Sciences en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1879-0720 en
pubs.record-created-at-source-date 2017-03-03 en 2016-11-10 en
pubs.dimensions-id 27838251 en

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