Controlling gelation with sequence: towards programmable peptide hydrogels

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Show simple item record Medini, Karima en Mansel, BW en Williams, MA en Brimble, Margaret en Williams, David en Gerrard, Juliet en 2017-03-16T01:40:06Z en 2016-10-01 en
dc.identifier.citation Acta Biomaterialia 43:30-37 01 Oct 2016 en
dc.identifier.issn 1742-7061 en
dc.identifier.uri en
dc.description.abstract The self-assembling peptide IKHLSVN, inspired by inspection of a protein-protein interface, has previously been reported as one of a new class of bio-inspired peptides. Here the peptide, dubbed littleSven, and modifications designed to probe the resilience of the sequence to self-assembly, is characterised. Although the parent peptide did not form a hydrogel, small modifications to the sequence (one side chain or an N-terminus modification) led to hydrogels with properties (eg. gelation time and rheology) that could be tuned by these small alterations. The results suggest that peptides derived from protein-protein interfaces are resilient to changes in sequence and can be harnessed to form hydrogels with controlled properties.Natural occurring self-assembly peptides are attractive building blocks for engineered bionanomaterials due to their biocompatibility and biodegradability. The bio-inspired self-assembly peptide, IKHLSVN, was used as a template to design peptides that readily formed hydrogels. The peptide sequence was specifically tuned to create a bionanomaterial with different properties that could be exploited downstream for a broad range of applications: nanowires, drug release, vaccine adjuvant, tissue engineering. We describe how small modifications to the parent peptide alter the amyloid-like characteristics and gel strength for each peptide. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher Elsevier BV en
dc.relation.ispartofseries Acta Biomaterialia en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Controlling gelation with sequence: towards programmable peptide hydrogels en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.actbio.2016.07.021 en
pubs.begin-page 30 en
pubs.volume 43 en
dc.rights.holder Copyright: Elsevier BV en
dc.identifier.pmid 27424085 en
pubs.end-page 37 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 536227 en Science en Biological Sciences en Chemistry en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1878-7568 en
pubs.record-created-at-source-date 2017-03-16 en 2016-07-13 en
pubs.dimensions-id 27424085 en

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