Sequential Pattern Formation in the Cerebellar Granular Layer

Show simple item record Bratby, P en Sneyd, A en Montgomery, John en 2017-03-16T22:42:12Z en 2017-04 en
dc.identifier.citation Cerebellum 16(2):438-449 Apr 2017 en
dc.identifier.issn 1473-4222 en
dc.identifier.uri en
dc.description.abstract Here, we introduce a novel mechanism for temporal recoding by the cerebellar granular layer based on three key properties: the granule cell-Golgi cell inhibitory feedback loop, bursting behaviour of granule cells and the large ratio of granule cells to Golgi cells. We propose that mutual inhibition of granule cells, mediated by Golgi cell feedback inhibition, prevents simultaneous activation. Granule cells are differentiated by firing threshold, resulting in sequential bursts of spikes. We demonstrate the plausibility of the mechanism through a computational simulation of a firing rate model, and further examine its robustness by developing a spiking model incorporating realistic postsynaptic potentials. en
dc.publisher Springer New York en
dc.relation.ispartofseries Cerebellum en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Sequential Pattern Formation in the Cerebellar Granular Layer en
dc.type Journal Article en
dc.identifier.doi 10.1007/s12311-016-0820-y en
pubs.issue 2 en
pubs.begin-page 438 en
pubs.volume 16 en
dc.rights.holder Copyright: Springer New York en
dc.identifier.pmid 27543118 en
pubs.end-page 449 en
pubs.publication-status Published online en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 540605 en Science en Marine Science en Mathematics en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1473-4230 en
pubs.record-created-at-source-date 2017-03-17 en 2016-08-20 en
pubs.dimensions-id 27543118 en

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