dc.contributor.author |
Bratby, P |
en |
dc.contributor.author |
Sneyd, A |
en |
dc.contributor.author |
Montgomery, John |
en |
dc.date.accessioned |
2017-03-16T22:42:12Z |
en |
dc.date.issued |
2017-04 |
en |
dc.identifier.citation |
Cerebellum 16(2):438-449 Apr 2017 |
en |
dc.identifier.issn |
1473-4222 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/32219 |
en |
dc.description.abstract |
Here, we introduce a novel mechanism for temporal recoding by the cerebellar granular layer based on three key properties: the granule cell-Golgi cell inhibitory feedback loop, bursting behaviour of granule cells and the large ratio of granule cells to Golgi cells. We propose that mutual inhibition of granule cells, mediated by Golgi cell feedback inhibition, prevents simultaneous activation. Granule cells are differentiated by firing threshold, resulting in sequential bursts of spikes. We demonstrate the plausibility of the mechanism through a computational simulation of a firing rate model, and further examine its robustness by developing a spiking model incorporating realistic postsynaptic potentials. |
en |
dc.publisher |
Springer New York |
en |
dc.relation.ispartofseries |
Cerebellum |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Sequential Pattern Formation in the Cerebellar Granular Layer |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s12311-016-0820-y |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
438 |
en |
pubs.volume |
16 |
en |
dc.rights.holder |
Copyright: Springer New York |
en |
dc.identifier.pmid |
27543118 |
en |
pubs.end-page |
449 |
en |
pubs.publication-status |
Published online |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
540605 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Marine Science |
en |
pubs.org-id |
Mathematics |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1473-4230 |
en |
pubs.record-created-at-source-date |
2017-03-17 |
en |
pubs.online-publication-date |
2016-08-20 |
en |
pubs.dimensions-id |
27543118 |
en |