Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer’s Disease

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dc.contributor.author Kwakowsky, Andrea en
dc.contributor.author Milne, M en
dc.contributor.author Waldvogel, Henry en
dc.contributor.author Faull, Richard en
dc.date.accessioned 2017-04-02T22:02:01Z en
dc.date.issued 2016-12 en
dc.identifier.citation International Journal of Molecular Sciences 17(12):28 pages Article number 2122 Dec 2016 en
dc.identifier.issn 1661-6596 en
dc.identifier.uri http://hdl.handle.net/2292/32410 en
dc.description.abstract The basal forebrain is home to the largest population of cholinergic neurons in the brain. These neurons are involved in a number of cognitive functions including attention, learning and memory. Basal forebrain cholinergic neurons (BFCNs) are particularly vulnerable in a number of neurological diseases with the most notable being Alzheimer’s disease, with evidence for a link between decreasing cholinergic markers and the degree of cognitive impairment. The neurotrophin growth factor system is present on these BFCNs and has been shown to promote survival and differentiation on these neurons. Clinical and animal model studies have demonstrated the neuroprotective effects of 17β-estradiol (E2) on neurodegeneration in BFCNs. It is believed that E2 interacts with neurotrophin signaling on cholinergic neurons to mediate these beneficial effects. Evidence presented in our recent study confirms that altering the levels of circulating E2 levels via ovariectomy and E2 replacement significantly affects the expression of the neurotrophin receptors on BFCN. However, we also showed that E2 differentially regulates neurotrophin receptor expression on BFCNs with effects depending on neurotrophin receptor type and neuroanatomical location. In this review, we aim to survey the current literature to understand the influence of E2 on the neurotrophin system, and the receptors and signaling pathways it mediates on BFCN. In addition, we summarize the physiological and pathophysiological significance of E2 actions on the neurotrophin system in BFCN, especially focusing on changes related to Alzheimer’s disease. en
dc.publisher MDPI AG en
dc.relation.ispartofseries International Journal of Molecular Sciences en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1661-6596/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.title Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer’s Disease en
dc.type Journal Article en
dc.identifier.doi 10.3390/ijms17122122 en
pubs.issue 12 en
pubs.volume 17 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: MDPI AG en
dc.identifier.pmid 27999310 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 603730 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Anatomy and Medical Imaging en
dc.identifier.eissn 1422-0067 en
pubs.number 2122 en
pubs.record-created-at-source-date 2017-04-03 en
pubs.online-publication-date 2016-12-17 en
pubs.dimensions-id 27999310 en


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