dc.contributor.author |
Geraerts, FCA |
en |
dc.contributor.author |
Snell, Russell |
en |
dc.contributor.author |
Faull, Richard |
en |
dc.contributor.author |
Williams, L |
en |
dc.contributor.author |
Jacobsen, Jessie |
en |
dc.contributor.author |
Reid, Susanne |
en |
dc.date.accessioned |
2017-04-02T22:52:21Z |
en |
dc.date.issued |
2016-10-01 |
en |
dc.identifier.citation |
Journal of Huntington's Disease, 01 Oct 2016, 5 (3), 297 - 301 |
en |
dc.identifier.issn |
1879-6397 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/32413 |
en |
dc.description.abstract |
Huntington’s disease is caused by expansion of the CAG repeat in Huntingtin. This repeat has shown tissue-specific instability in mouse models and in a small number of post-mortem human samples. We used small-pool PCR to generate a modified instability index to quantify CAG instability within two brain regions from six human samples where cell loss has been associated with motor and mood symptoms: the motor cortex and cingulate gyrus. The expanded allele demonstrated instability in both regions, with minimal instability in the unexpanded allele. Region-specific differences were not observed, suggesting symptomatology may not be determined by repeat length instability. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/27716680 |
en |
dc.language |
English |
en |
dc.publisher |
IOS Press |
en |
dc.relation.ispartofseries |
Journal of Huntington's Disease |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1879-6397/
http://www.iospress.nl/service/authors/author-copyright-agreement/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Comparison of Huntington’s disease CAG Repeat Length Stability in Human Motor Cortex and Cingulate Gyrus |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.3233/JHD-160203 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
297 |
en |
pubs.volume |
5 |
en |
dc.description.version |
VoR - Version of Record |
en |
dc.identifier.pmid |
27716680 |
en |
pubs.author-url |
http://content.iospress.com/articles/journal-of-huntingtons-disease/jhd160203 |
en |
pubs.end-page |
301 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
542531 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
dc.identifier.eissn |
1879-6400 |
en |
pubs.record-created-at-source-date |
2017-04-03 |
en |
pubs.dimensions-id |
27716680 |
en |