Metabolite Profile of Cervicovaginal Fluids from Early Pregnancy Is Not Predictive of Spontaneous Preterm Birth

Show simple item record Thomas, Melinda en Sulek, Karolina en McKenzie, Elizabeth en Jones, B en Han, Ting-Li en Villas-Boas, Silas en Kenny, LC en McCowan, Lesley en Baker, Philip en 2017-04-03T04:24:09Z en 2015-11-06 en 2015-11-19 en
dc.identifier.citation International journal of molecular sciences, 19 November 2015, 16 (11), 27741 - 27748 en
dc.identifier.issn 1661-6596 en
dc.identifier.uri en
dc.description.abstract In our study, we used a mass spectrometry-based metabolomic approach to search for biomarkers that may act as early indicators of spontaneous preterm birth (sPTB). Samples were selected as a nested case-control study from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Cervicovaginal swabs were collected at 20 weeks from women who were originally assessed as being at low risk of sPTB. Samples were analysed using gas chromatography-mass spectrometry (GC-MS). Despite the low amount of biomass (16-23 mg), 112 compounds were detected. Statistical analysis showed no significant correlations with sPTB. Comparison of reported infection and plasma inflammatory markers from early pregnancy showed two inflammatory markers were correlated with reported infection, but no correlation with any compounds in the metabolite profile was observed. We hypothesise that the lack of biomarkers of sPTB in the cervicovaginal fluid metabolome is simply because it lacks such markers in early pregnancy. We propose alternative biofluids be investigated for markers of sPTB. Our results lead us to call for greater scrutiny of previously published metabolomic data relating to biomarkers of sPTB in cervicovaginal fluids, as the use of small, high risk, or late pregnancy cohorts may identify metabolite biomarkers that are irrelevant for predicting risk in normal populations. en
dc.description.uri en
dc.format.medium Electronic en
dc.language English en
dc.publisher MDPI en
dc.relation.ispartofseries International journal of molecular sciences en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
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dc.title Metabolite Profile of Cervicovaginal Fluids from Early Pregnancy Is Not Predictive of Spontaneous Preterm Birth en
dc.type Journal Article en
dc.identifier.doi 10.3390/ijms161126052 en
pubs.issue 11 en
pubs.begin-page 27741 en
pubs.volume 16 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 26610472 en en
pubs.end-page 27748 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 510278 en Academic Services en Examinations en Medical and Health Sciences en School of Medicine en Obstetrics and Gynaecology en Science en Statistics en
dc.identifier.eissn 1422-0067 en
pubs.record-created-at-source-date 2017-04-03 en
pubs.dimensions-id 26610472 en

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