The tuberculocidal activity of polyaniline and functionalised polyanilines

Show simple item record Robertson, Julia en Dalton, J en Wiles, Siouxsie en Gizdavic Nikolaidis, Marija en Swift, Simon en 2017-04-20T03:19:36Z en 2016-12 en
dc.identifier.citation PeerJ 4:15 pages Article number e2795 Dec 2016 en
dc.identifier.issn 2167-8359 en
dc.identifier.uri en
dc.description.abstract Tuberculosis is considered a leading cause of death worldwide. More than 95% of cases and deaths occur in low- and middle-income countries. In resource-limited countries, hospitals often lack adequate facilities to manage and isolate patients with infectious tuberculosis (TB), relying instead on personal protective equipment, such as facemasks, to reduce nosocomial transmission of the disease. Facemasks impregnated with an antimicrobial agent may be a cost-effective way of adding an extra level of protection against the spread of TB by reducing the risk of disease transmission. Conducting polymers, such as polyaniline (PANI), and their functionalised derivatives are a novel class of antimicrobial agents with potential as non-leaching additives to provide contamination resistant surfaces. We have investigated the antimicrobial action of PANI and a functionalised derivative, poly-3-aminobenzoic acid (P3ABA), against mycobacteria and have determined the optimal treatment time and concentration to achieve significant knockdown of Mycobacterium smegmatis and Mycobacterium tuberculosis on an agar surface. Results indicated that P3ABA is a potential candidate for use as an anti-tuberculoid agent in facemasks to reduce TB transmission. en
dc.publisher PeerJ Inc. en
dc.relation.ispartofseries PeerJ en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
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dc.title The tuberculocidal activity of polyaniline and functionalised polyanilines en
dc.type Journal Article en
dc.identifier.doi 10.7717/peerj.2795 en
pubs.volume 4 en
dc.description.version AM - Accepted Manuscript en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 28028468 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 605516 en Medical and Health Sciences en Medical Sciences en Molecular Medicine en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 2167-8359 en
pubs.number e2795 en
pubs.record-created-at-source-date 2017-04-20 en 2016-12-20 en
pubs.dimensions-id 28028468 en

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