Atlas-based ventricular shape analysis for understanding congenital heart disease

Show simple item record Farrar, G en Suinesiaputra, Avan en Gilbert, Kathleen en Perry, JC en Hegde, S en Marsden, A en Young, Alistair en Omens, JH en McCulloch, AD en 2017-04-27T03:08:49Z en 2016-12 en
dc.identifier.citation Progress in Pediatric Cardiology 43:61-69 Dec 2016 en
dc.identifier.issn 1058-9813 en
dc.identifier.uri en
dc.description.abstract Congenital heart disease is associated with abnormal ventricular shape that can affect wall mechanics and may be predictive of long-term adverse outcomes. Atlas-based parametric shape analysis was used to analyze ventricular geometries of eight adolescent or adult single-ventricle CHD patients with tricuspid atresia and Fontans. These patients were compared with an “atlas” of non-congenital asymptomatic volunteers, resulting in a set of Z-scores which quantify deviations from the control population distribution on a patient-by-patient basis. We examined the potential of these scores to: (1) quantify abnormalities of ventricular geometry in single ventricle physiologies relative to the normal population; (2) comprehensively quantify wall motion in CHD patients; and (3) identify possible relationships between ventricular shape and wall motion that may reflect underlying functional defects or remodeling in CHD patients. CHD ventricular geometries at end-diastole and end-systole were individually compared with statistical shape properties of an asymptomatic population from the Cardiac Atlas Project. Shape analysis-derived model properties, and myocardial wall motions between end-diastole and end-systole, were compared with physician observations of clinical functional parameters. Relationships between altered shape and altered function were evaluated via correlations between atlas-based shape and wall motion scores. Atlas-based shape analysis identified a diverse set of specific quantifiable abnormalities in ventricular geometry or myocardial wall motion in all subjects. Moreover, this initial cohort displayed significant relationships between specific shape abnormalities such as increased ventricular sphericity and functional defects in myocardial deformation, such as decreased long-axis wall motion. These findings suggest that atlas-based ventricular shape analysis may be a useful new tool in the management of patients with CHD who are at risk of impaired ventricular wall mechanics and chamber remodeling. en
dc.publisher Elsevier BV en
dc.relation.ispartofseries Progress in Pediatric Cardiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.title Atlas-based ventricular shape analysis for understanding congenital heart disease en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ppedcard.2016.07.010 en
pubs.begin-page 61 en
pubs.volume 43 en
dc.description.version AM - Accepted Manuscript en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 28082823 en
pubs.end-page 69 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 602914 en Bioengineering Institute en ABI Associates en Medical and Health Sciences en Medical Sciences en Anatomy and Medical Imaging en
pubs.record-created-at-source-date 2017-04-27 en
pubs.dimensions-id 28082823 en

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