dc.contributor.author |
Beier, Susann |
en |
dc.contributor.author |
Ormiston, J |
en |
dc.contributor.author |
Webster, M |
en |
dc.contributor.author |
Cater, John |
en |
dc.contributor.author |
Norris, Stuart |
en |
dc.contributor.author |
Medrano Gracia, P |
en |
dc.contributor.author |
Young, Alistair |
en |
dc.contributor.author |
Gilbert, Kathleen |
en |
dc.contributor.author |
Cowan, Brett |
en |
dc.coverage.spatial |
Orlando, Florida |
en |
dc.date.accessioned |
2017-05-04T00:50:03Z |
en |
dc.date.issued |
2016-10-18 |
en |
dc.identifier.citation |
38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, Florida, 16 Aug 2016 - 20 Aug 2016. Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE. 1220-1223. 18 Oct 2016 |
en |
dc.identifier.isbn |
9781457702204 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/32764 |
en |
dc.description.abstract |
The majority of patients with angina or heart failure have coronary artery disease. Left main bifurcations are particularly susceptible to pathological narrowing. Flow is a major factor of atheroma development, but limitations in imaging technology such as spatio-temporal resolution, signal-to-noise ratio (SNRv), and imaging artefacts prevent in vivo investigations. Computational fluid dynamics (CFD) modelling is a common numerical approach to study flow, but it requires a cautious and rigorous application for meaningful results. Left main bifurcation angles of 40°, 80° and 110° were found to represent the spread of an atlas based 100 computed tomography angiograms. Three left mains with these bifurcation angles were reconstructed with 1) idealized, 2) stented, and 3) patient-specific geometry. These were then approximately 7× scaled-up and 3D printing as large phantoms. Their flow was reproduced using a blood-analogous, dynamically scaled steady flow circuit, enabling in vitro phase-contrast magnetic resonance (PC-MRI) measurements. After threshold segmentation the image data was registered to true-scale CFD of the same coronary geometry using a coherent point drift algorithm, yielding a small covariance error (σ2 <;5.8×10-4). Natural-neighbour interpolation of the CFD data onto the PC-MRI grid enabled direct flow field comparison, showing very good agreement in magnitude (error 2-12%) and directional changes (r2 0.87-0.91), and stent induced flow alternations were measureable for the first time. PC-MRI over-estimated velocities close to the wall, possibly due to partial voluming. Bifurcation shape determined the development of slow flow regions, which created lower SNRv regions and increased discrepancies. These can likely be minimised in future by testing different similarity parameters to reduce acquisition error and improve correlation further. It was demonstrated that in vitro large phantom acquisition correlates to true-scale coronary flow simulations when dynamically scaled, and thus can overcome current PC-MRI's spatio-temporal limitations. This novel method enables experimental assessment of stent induced flow alternations, and in future may elevate CFD coronary flow simulations by providing sophisticated boundary conditions, and enable investigations of stenosis phantoms. |
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dc.publisher |
IEEE |
en |
dc.relation.ispartof |
38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
en |
dc.relation.ispartofseries |
Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Overcoming spatio-temporal limitations using dynamically scaled in vitro PC-MRI — A flow field comparison to true-scale computer simulations of idealized, stented and patient-specific left main bifurcations |
en |
dc.type |
Conference Item |
en |
dc.identifier.doi |
10.1109/EMBC.2016.7590925 |
en |
pubs.begin-page |
1220 |
en |
dc.rights.holder |
Copyright: IEEE |
en |
dc.identifier.pmid |
28324943 |
en |
pubs.end-page |
1223 |
en |
pubs.finish-date |
2016-08-20 |
en |
pubs.start-date |
2016-08-16 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Proceedings |
en |
pubs.elements-id |
609022 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Mechanical Engineering |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
pubs.record-created-at-source-date |
2017-01-20 |
en |
pubs.dimensions-id |
28324943 |
en |