dc.contributor.author |
Khan, AA |
en |
dc.contributor.author |
Morrison, A |
en |
dc.contributor.author |
Kendler, DL |
en |
dc.contributor.author |
Rizzoli, R |
en |
dc.contributor.author |
Hanley, DA |
en |
dc.contributor.author |
Felsenberg, D |
en |
dc.contributor.author |
McCauley, LK |
en |
dc.contributor.author |
O'Ryan, F |
en |
dc.contributor.author |
Reid, Ian |
en |
dc.contributor.author |
Ruggiero, SL |
en |
dc.contributor.author |
Taguchi, A |
en |
dc.contributor.author |
Tetradis, S |
en |
dc.contributor.author |
Watts, NB |
en |
dc.contributor.author |
Brandi, ML |
en |
dc.contributor.author |
Peters, E |
en |
dc.contributor.author |
Guise, T |
en |
dc.contributor.author |
Eastell, R |
en |
dc.contributor.author |
Cheung, AM |
en |
dc.contributor.author |
Morin, SN |
en |
dc.contributor.author |
Masri, B |
en |
dc.contributor.author |
Cooper, C |
en |
dc.contributor.author |
Morgan, SL |
en |
dc.contributor.author |
Obermayer-Pietsch, B |
en |
dc.contributor.author |
Langdahl, BL |
en |
dc.contributor.author |
Dabagh, RA |
en |
dc.contributor.author |
Davison, KS |
en |
dc.contributor.author |
Sándor, GK |
en |
dc.contributor.author |
Josse, RG |
en |
dc.contributor.author |
Bhandari, M |
en |
dc.contributor.author |
El Rabbany, M |
en |
dc.contributor.author |
Pierroz, DD |
en |
dc.contributor.author |
Sulimani, R |
en |
dc.contributor.author |
Saunders, DP |
en |
dc.contributor.author |
Brown, JP |
en |
dc.contributor.author |
Compston, J |
en |
dc.date.accessioned |
2017-05-04T05:18:39Z |
en |
dc.date.issued |
2017-01 |
en |
dc.identifier.citation |
Journal of Clinical Densitometry 20(1):8-24 Jan 2017 |
en |
dc.identifier.issn |
1094-6950 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/32772 |
en |
dc.description.abstract |
Osteonecrosis of the jaw (ONJ) has been associated with antiresorptive therapy in both oncology and osteoporosis patients. This debilitating condition is very rare and advances in diagnosis and management may now effectively reduce the risk of its development and offer valuable treatment options for affected patients. This paper provides a case-based review of ONJ and application of the International Task Force on ONJ (referred to as the "Task Force") recommendations for the diagnosis and management of ONJ. The Task Force was supported by 14 international societies and achieved consensus from representatives of these multidisciplinary societies on key issues pertaining to the diagnosis and management of ONJ. The frequency of ONJ in oncology patients receiving oncology doses of bisphosphonate (BP) or denosumab is estimated at 1%-15%, and the frequency in the osteoporosis patient population receiving much lower doses of BP or denosumab is estimated at 0.001%-0.01%. Although the diagnosis of ONJ is primarily clinical, imaging may be helpful in confirming the diagnosis and staging. In those with multiple risk factors for ONJ for whom major invasive oral surgery is being planned, interruption of BP or denosumab therapy (in cancer patients) is advised, if possible, before surgery, until the surgical site heals. Major oral surgery in this context could include multiple extractions if surgical extractions are required, not simple forceps extractions. ONJ development may be reduced by optimizing oral hygiene and postoperatively using topical and systemic antibiotics as appropriate. Periodontal disease should be managed before starting oncology doses of BP or denosumab. Local debridement may be successful in disease unresponsive to conservative therapy. Successful surgical intervention has been reported in those with stage 3 disease; less severe disease is best managed conservatively. Teriparatide may be helpful in healing ONJ lesions and may be considered in osteoporosis patients at a high fracture risk in the absence of contraindications. Resumption of BP or denosumab therapy following healing of ONJ lesions is recommended, and there have not been reports of subsequent local recurrence. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
Humana Press, Inc. |
en |
dc.relation.ispartofseries |
Journal of Clinical Densitometry |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
International Task Force on Osteonecrosis of the Jaw |
en |
dc.title |
Case-Based Review of Osteonecrosis of the Jaw (ONJ) and Application of the International Recommendations for Management From the International Task Force on ONJ |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.jocd.2016.09.005 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
8 |
en |
pubs.volume |
20 |
en |
dc.rights.holder |
Copyright: Humana Press, Inc. |
en |
dc.identifier.pmid |
27956123 |
en |
pubs.end-page |
24 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
603750 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2017-05-04 |
en |
pubs.dimensions-id |
27956123 |
en |