Synthesis of Clausenal from Carbazole Using Sequential C–H Borylations

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dc.contributor.advisor Sperry, J en
dc.contributor.author Liyu, Jessica en
dc.date.accessioned 2017-05-22T22:20:19Z en
dc.date.issued 2017 en
dc.identifier.uri http://hdl.handle.net/2292/32998 en
dc.description Full text is available to authenticated members of The University of Auckland only. en
dc.description.abstract Carbazoles represent an enormous family of alkaloids with a vast array of biological properties, inspiring dozens of total syntheses of these natural products. The strategies used to synthesize carbazoles are overwhelmingly reliant on one or more (hetero)cyclization reactions. Conceptually, the simplest way to construct substituted carbazoles would be to subject a simple carbazole core to several C–H functionalization reactions, negating the need for any cyclization steps. In this regard, this thesis describes the successful development of a conceptually disparate approach to carbazole synthesis. By subjecting readily available, cheap carbazole to sequential C-H functionalization reactions, the synthesis of the natural product clausenal was achieved in a route devoid of cyclization reactions. The spectroscopic data for the natural product was in full agreement with the literature. en
dc.publisher ResearchSpace@Auckland en
dc.relation.ispartof Masters Thesis - University of Auckland en
dc.relation.isreferencedby UoA99264918809102091 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights Restricted Item. Available to authenticated members of The University of Auckland. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/nz/ en
dc.title Synthesis of Clausenal from Carbazole Using Sequential C–H Borylations en
dc.type Thesis en
thesis.degree.discipline Chemistry en
thesis.degree.grantor The University of Auckland en
thesis.degree.level Masters en
dc.rights.holder Copyright: The author en
pubs.elements-id 626915 en
pubs.record-created-at-source-date 2017-05-23 en


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