Clinical and biochemical factors associated with preeclampsia in women with obesity.

Show simple item record Vieira, MC en Poston, L en Fyfe, E en Gillett, A en Kenny, LC en Roberts, CT en Baker, Philip en Myers, JE en Walker, JJ en McCowan, Lesley en North, RA en Pasupathy, D en 2017-05-23T03:02:55Z en 2017-02 en
dc.identifier.citation Obesity 25(2):460-467 Feb 2017 en
dc.identifier.uri en
dc.description.abstract To compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI ≥30 kg/m2 ) and those with a normal BMI (20-25 kg/m2 ).In 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study, a total of 53 biomarkers of glucose and lipid metabolism, placental function, and known markers of preeclampsia were measured at 14 to 16 weeks' gestation. Logistic regression was performed to identify clinical and biomarker risk factors for preeclampsia in women with and without obesity.Among 834 women with obesity and 3,106 with a normal BMI, 77 (9.2%) and 105 (3.4%) developed preeclampsia, respectively. In women with obesity, risk factors included a family history of thrombotic disease, low plasma placental growth factor, and higher uterine artery resistance index at 20 weeks. In women with a normal BMI, a family history of preeclampsia or gestational hypertension, mean arterial blood pressure, plasma endoglin and cystatin C, and uterine artery resistance index were associated with preeclampsia, while high fruit intake was protective.Women with obesity and a normal BMI have different early pregnancy clinical and biomarker risk factors for preeclampsia. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher Wiley en
dc.relation.ispartofseries Obesity en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject SCOPE Consortium en
dc.title Clinical and biochemical factors associated with preeclampsia in women with obesity. en
dc.type Journal Article en
dc.identifier.doi 10.1002/oby.21715 en
pubs.issue 2 en
pubs.begin-page 460 en
pubs.volume 25 en
dc.rights.holder Copyright: Wiley en
dc.identifier.pmid 28008746 en
pubs.end-page 467 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 604257 en Medical and Health Sciences en School of Medicine en Obstetrics and Gynaecology en
dc.identifier.eissn 1930-739X en
pubs.record-created-at-source-date 2017-05-23 en
pubs.dimensions-id 28008746 en

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