Origins of Pupillary Hippus in the Autonomic Nervous System

Show simple item record Turnbull, Philip en Irani, N en Lim, N en Phillips, John en 2017-05-28T21:25:37Z en 2017-01 en
dc.identifier.citation Investigative Ophthalmology & Visual Science 58(1):197-203 Jan 2017 en
dc.identifier.issn 0146-0404 en
dc.identifier.uri en
dc.description.abstract The purpose of this study was to determine the relative roles of the sympathetic (SNS) and parasympathetic nervous system (PNS) in pupillary hippus.We used a paired-eye control study design with three cohorts receiving either 1.0% tropicamide (PNS antagonist) in light (TL), 1.0% tropicamide in dark (TD), or 10% phenylephrine (SNS) in light (PL), n = 12 in each. Each subject received one drop to the randomly determined treatment eye, while the other eye served as control. Bilateral measures of pupil size and dynamics were made over 2.6 seconds using an infrared eye-tracker sampling at 500 Hz. Measures were taken at baseline, then every 5 minutes for 40 minutes. Hippus, analyzed in both time and frequency domains, was compared between eyes and cohorts.Pupillary hippus with a distinct dominant frequency was present in all measures at baseline (mean: 0.62 Hz, SD: 0.213 Hz), and that frequency did not change in any group (P = 0.971). Hippus magnitude (treatment eye relative to control eye) decreased in the TL (-72.8 ± 4.7%, P < 0.0001) and TD (-71.3 ± 2.6%, P < 0.0001) groups, but did not change in the PL (+5.4 ± 13.7%, P = 0.173) group, despite PL pupils dilating to a proportion similar to TD.Pupillary hippus can be extinguished by antagonizing the PNS, whereas agonizing the SNS dilates the pupil without affecting hippus. This suggests that hippus originates from central PNS activity, and not from SNS activity, or oscillations in the balance between PNS and SNS at the pupil. en
dc.format.medium Print en
dc.language eng en
dc.publisher Association for Research in Vision and Ophthalmology en
dc.relation.ispartofseries Investigative Ophthalmology & Visual Science en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.title Origins of Pupillary Hippus in the Autonomic Nervous System en
dc.type Journal Article en
dc.identifier.doi 10.1167/iovs.16-20785 en
pubs.issue 1 en
pubs.begin-page 197 en
pubs.volume 58 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: The author en
dc.identifier.pmid 28114580 en
pubs.end-page 203 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 611782 en Medical and Health Sciences en Optometry and Vision Science en
dc.identifier.eissn 1552-5783 en
pubs.record-created-at-source-date 2017-05-25 en
pubs.dimensions-id 28114580 en

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