Metabolic outcomes after an 8 weeks low-calorie-diet in overweight, pre-diabetic individuals: the role of gender in the PREVIEW study

Show simple item record Christensen, P en Fogelholm, M en Westerterp-Plantenga, M en Macdonald, I en Martinez, A en Handjiev, S en Brand-Miller, J en Poppitt, Sally en Schlicht, W en Astrup, A en Hovi, E en Drummen, M en Taylor, M en Navas-Carretero, S en Handjiev-Darlenska, S en Brodie, S en Silvestre, M en Kahlert, D en Larsen, T en Raben, A en
dc.coverage.spatial Gothenberg, Sweden en 2017-05-31T00:27:26Z en 2016-06 en
dc.identifier.citation European Obesity Summit (EOS) – Joint Congress of EASO and IFSO-EC, Gothenberg, Sweden, 01 Jun 2016 - 04 Jun 2016. Obesity Facts. S. Karger AG. 9: 48-48. Jun 2016 en
dc.identifier.issn 1662-4025 en
dc.identifier.uri en
dc.description.abstract Background & Aims: Lifestyle intervention remains the corner stone in prevention and management of type-2 diabetes (T2D). The PREVIEW intervention study ( is to date the largest, multinational study with the aim of preventing T2D among pre-diabetic individuals with a combination of diet, physical activity and behavior modification. Initially, all participants follow a formula low-calorie diet (LCD) to achieve a significant weight loss (≥8% of initial body weight, BW). Although the majority of participants in LCD weight loss studies are women, very little attention has been paid to the role of gender. Objectives: To compare the effect of 8 weeks’ LCD on weight loss and metabolic outcomes between pre-diabetic men and women. Material & methods The participants received LCD [810 kcal daily] for 8 weeks (Cambridge Weight Plan®). Data from participants who achieved 8% weight loss were included in the analysis. Two-sided t-tests were used throughout. Linear regressions were applied to test correlations. Results: Of 2,326 individuals eligible for the LCD period, a total of 1,842 (79%) participants (1,225 women and 617 men) completed the weight loss phase successfully. At baseline, mean (±SD) age was 51.6±11.6 years, BMI 35.3±6.5 kg/m2, fasting plasma glucose 6.2±0.7 mmol/L, and fasting serum insulin 13.4±7.8 mU/L. Average weight loss was 10.6+/-4.0 kg, with men losing 12.7+/-4.2kg and women 9.6+/-3.4 kg (difference between gender, P < 0.001). The men lost 11.7+/-3.5% of initial BW where the women lost 10.2+/-3.1% (P < 0.001). Fasting plasma glucose decreased by 0.57+/-0.7 mmol/L in men, and by 0.37 +/-0.6 mmol/L in women (P < 0.001). Fasting serum insulin decreased by 5.8+/-7.4 mU/L in men and by 3.8+/-5.4 mU/L in women (P < 0.001). The linear model showed an association of the weight loss percentage as well as gender on the changes in glucose and insulin. Conclusion: An 8 weeks’ LCD intervention resulted in a marked decrease in body weight, fasting glucose and insulin among pre-diabetic subjects. Significantly larger decreases were seen in men versus women. Funding EU FP7, grant agreement 312057; NHMRC – EU Collaborative Grant, AUS; NZ Health Research Council (14/191), UoA Faculty Research Development Fund; The Cambridge Weight Plan has kindly donated all LCD products. en
dc.publisher S. Karger AG en
dc.relation.ispartof European Obesity Summit (EOS) – Joint Congress of EASO and IFSO-EC en
dc.relation.ispartofseries Obesity Facts en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.rights.uri en
dc.title Metabolic outcomes after an 8 weeks low-calorie-diet in overweight, pre-diabetic individuals: the role of gender in the PREVIEW study en
dc.type Conference Item en
dc.identifier.doi 10.1159/000446744 en
pubs.issue S1 en
pubs.begin-page 48 en
pubs.volume 9 en
dc.description.version AM - Accepted Manuscript en
dc.rights.holder Copyright: The authors en en
pubs.end-page 48 en
pubs.finish-date 2016-06-04 en
pubs.start-date 2016-06-01 en
dc.rights.accessrights en
pubs.subtype Abstract en
pubs.elements-id 612543 en
dc.relation.isnodouble 658919 * Science en Biological Sciences en
dc.identifier.eissn 1662-4033 en
pubs.record-created-at-source-date 2017-02-14 en

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