Neonatal pharmacology

Show simple item record Anderson, Brian en 2017-06-01T05:15:31Z en 2017-02 en
dc.identifier.citation Anaesthesia and Intensive Care Medicine 18(2):68-74 Feb 2017 en
dc.identifier.issn 1472-0299 en
dc.identifier.uri en
dc.description.abstract Neonatal anaesthesia dosing needs to be based on physiological characteristics of the newborn, pharmacokinetic knowledge, pharmacodynamic considerations and the adverse effects profile. Disease processes and treatments in this group are distinct from adults. Immaturity of enzyme, anatomical and physiological systems cause extensive variability of drug disposition and drug response in neonates. This is further compounded by pharmacogenomic influences. Postmenstrual age is a reasonable measure for maturation of clearance pathways. The neonatal response to drugs is altered and monitoring of effect that guides adult drug use is limited. While neuromuscular monitoring is robust, few other clinically applicable tools are available to provide pharmacodynamic effect feedback. Tools that assess depth of anaesthesia, sedation and pain in neonates have potential to improve effectiveness and safety. en
dc.publisher Medicine Pub. Co. en
dc.relation.ispartofseries Anaesthesia and Intensive Care Medicine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Neonatal pharmacology en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.mpaic.2016.11.007 en
pubs.issue 2 en
pubs.begin-page 68 en
pubs.volume 18 en
dc.rights.holder Copyright: Medicine Pub. Co. en
pubs.end-page 74 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 609922 en Medical and Health Sciences en School of Medicine en Anaesthesiology en
pubs.record-created-at-source-date 2017-06-01 en

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