Dietary omega-6 fatty acid replacement selectively impairs cardiac functional recovery after ischemia in female (but not male) rats

Show simple item record Ip, WTK en McAlindon, A en Miller, SE en Bell, JR en Curl, CL en Huggins, CE en Mellor, Kimberley en Raaijmakers, AJA en Bienvenu, LA en McLennan, PL en Pepe, S en Delbridge, Leanne en 2017-06-06T03:11:00Z en 2016-09 en
dc.identifier.citation American Journal of Physiology - Heart and Circulatory Physiology H768-H780 Sep 2016 en
dc.identifier.issn 0363-6135 en
dc.identifier.uri en
dc.description.abstract A definitive understanding of the role of dietary lipids in determining cardioprotection (or cardiodetriment) has been elusive. Randomized trial findings have been variable and sex specificity of dietary interventions has not been determined. In this investigation the sex-selective cardiac functional effects of three diets enriched by omega-3 or omega-6 polyunsaturated fatty acids (PUFA) or enriched to an equivalent extent in saturated fatty acid components were examined in rats after an 8-wk treatment period. In females the myocardial membrane omega-6:omega-3 PUFA ratio was twofold higher than males in the omega-6 diet replacement group. In diets specified to be high in omega-3 PUFA or in saturated fat, this sex difference was not apparent. Isolated cardiomyocyte and heart Langendorff perfusion experiments were performed, and molecular measures of cell viability were assessed. Under basal conditions the contractile performance of omega-6 fed female cardiomyocytes and hearts was reduced compared with males. Omega-6 fed females exhibited impaired systolic resilience after ischemic insult. This response was associated with increased postischemia necrotic cell damage evaluated by coronary lactate dehydrogenase during reperfusion in omega-6 fed females. Cardiac and myocyte functional parameters were not different between omega-3 and saturated fat dietary groups and within these groups there were no discernible sex differences. Our data provide evidence at both the cardiac and cardiomyocyte levels that dietary saturated fatty acid intake replacement with an omega-6 (but not omega-3) enriched diet has selective adverse cardiac effect in females. This finding has potential relevance in relation to women, cardiac risk, and dietary management. en
dc.publisher American Physiological Society en
dc.relation.ispartofseries American Journal of Physiology - Heart and Circulatory Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Dietary omega-6 fatty acid replacement selectively impairs cardiac functional recovery after ischemia in female (but not male) rats en
dc.type Journal Article en
dc.identifier.doi 10.1152/ajpheart.00690.2015 en
pubs.begin-page H768 en
dc.rights.holder Copyright: American Physiological Society en
dc.identifier.pmid 27422989 en
pubs.end-page H780 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 540861 en Medical and Health Sciences en Medical Sciences en Physiology Division en
dc.identifier.eissn 1522-1539 en
pubs.record-created-at-source-date 2017-06-06 en
pubs.dimensions-id 27422989 en

Files in this item

There are no files associated with this item.

Find Full text

This item appears in the following Collection(s)

Show simple item record


Search ResearchSpace