The response to levodopa in Parkinson's disease: Imposing pharmacological law and order

ResearchSpace/Manakin Repository

Show simple item record

dc.contributor.author Nutt, JG en
dc.contributor.author Holford, Nicholas en
dc.date.accessioned 2017-06-07T04:47:38Z en
dc.date.available 1996-02-27 en
dc.date.issued 1996-05 en
dc.identifier.citation Annals of Neurology, May 1996, 39 (5), 561 - 573 en
dc.identifier.issn 0364-5134 en
dc.identifier.uri http://hdl.handle.net/2292/33323 en
dc.description.abstract The seemingly unpredictable response to levodopa in patients with Parkinson's disease can be understood as an interaction between several distinct pharmacological effects of levodopa. The most important are a short-duration response with a half-life of minutes to hours and a long-duration response with a half-life of days, superimposed on diurnal motor variation. A negative response characterized by brief worsening before and after the short-duration response and dyskinesia accentuate the short-duration response. These various responses are modified by disease progression and long-term levodopa therapy. Pharmacodynamic modeling of the short-duration response indicates that with time, the response becomes less graded and small changes in levodopa concentrations can produce big changes in response. In this setting, unpredictability arises from the variation in absorption and distribution of levodopa. en
dc.description.uri https://www.ncbi.nlm.nih.gov/pubmed/8619540 en
dc.language English en
dc.publisher Wiley / American Neurological Association en
dc.relation.ispartofseries Annals of Neurology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0364-5134/ https://authorservices.wiley.com/author-resources/Journal-Authors/licensing-open-access/open-access/self-archiving.html en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title The response to levodopa in Parkinson's disease: Imposing pharmacological law and order en
dc.type Journal Article en
pubs.issue 5 en
pubs.begin-page 561 en
pubs.volume 39 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 8619540 en
pubs.author-url http://onlinelibrary.wiley.com/doi/10.1002/ana.410390504/full en
pubs.end-page 573 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 8534 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Pharmacology en
dc.identifier.eissn 1531-8249 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.online-publication-date 2004-10-08 en
pubs.dimensions-id 8619540 en


Full text options

Find Full text

This item appears in the following Collection(s)

Show simple item record

Share

Search ResearchSpace


Advanced Search

Browse