The response to levodopa in Parkinson's disease: Imposing pharmacological law and order

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Show simple item record Nutt, JG en Holford, Nicholas en 2017-06-07T04:47:38Z en 1996-02-27 en 1996-05 en
dc.identifier.citation Annals of Neurology, May 1996, 39 (5), 561 - 573 en
dc.identifier.issn 0364-5134 en
dc.identifier.uri en
dc.description.abstract The seemingly unpredictable response to levodopa in patients with Parkinson's disease can be understood as an interaction between several distinct pharmacological effects of levodopa. The most important are a short-duration response with a half-life of minutes to hours and a long-duration response with a half-life of days, superimposed on diurnal motor variation. A negative response characterized by brief worsening before and after the short-duration response and dyskinesia accentuate the short-duration response. These various responses are modified by disease progression and long-term levodopa therapy. Pharmacodynamic modeling of the short-duration response indicates that with time, the response becomes less graded and small changes in levodopa concentrations can produce big changes in response. In this setting, unpredictability arises from the variation in absorption and distribution of levodopa. en
dc.description.uri en
dc.language English en
dc.publisher Wiley / American Neurological Association en
dc.relation.ispartofseries Annals of Neurology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title The response to levodopa in Parkinson's disease: Imposing pharmacological law and order en
dc.type Journal Article en
pubs.issue 5 en
pubs.begin-page 561 en
pubs.volume 39 en
dc.description.version VoR - Version of Record en
dc.identifier.pmid 8619540 en en
pubs.end-page 573 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 8534 en Medical and Health Sciences en Medical Sciences en Pharmacology en
dc.identifier.eissn 1531-8249 en
pubs.record-created-at-source-date 2010-09-01 en 2004-10-08 en
pubs.dimensions-id 8619540 en

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