dc.contributor.author |
Ambale-Venkatesh, B |
en |
dc.contributor.author |
Yoneyama, K |
en |
dc.contributor.author |
Sharma, RK |
en |
dc.contributor.author |
Ohyama, Y |
en |
dc.contributor.author |
Wu, CO |
en |
dc.contributor.author |
Burke, GL |
en |
dc.contributor.author |
Shea, S |
en |
dc.contributor.author |
Gomes, AS |
en |
dc.contributor.author |
Young, Alistair |
en |
dc.contributor.author |
Bluemke, DA |
en |
dc.contributor.author |
Lima, JA |
en |
dc.date.accessioned |
2017-06-09T02:18:38Z |
en |
dc.date.issued |
2017-04 |
en |
dc.identifier.citation |
Heart 103(7):499-507 Apr 2017 |
en |
dc.identifier.issn |
1355-6037 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/33384 |
en |
dc.description.abstract |
To investigate whether sphericity volume index (SVI), an indicator of left ventricular (LV) remodelling, predicts incident cardiovascular events (coronary heart disease, CHD; all cardiovascular disease, CVD; heart failure, HF; atrial fibrillation, AF) over 10 years of follow-up in a multiethnic population (Multi-Ethnic Study of Atherosclerosis).5004 participants free of known CVD had magnetic resonance imaging (MRI) in 2000-2002. Cine images were analysed to compute, [Formula: see text] equivalent to LV volume/volume of sphere with length of LV as the diameter. The highest (greatest sphericity) and lowest (lowest sphericity) quintiles of SVI were compared against the reference group (2-4 quintiles combined). Risk-factor adjusted hazard's ratio (HR) from Cox regression assessed the predictive performance of SVI at end-diastole (ED) and end-systole (ES) to predict incident outcomes over 10 years in retrospective interpretation of prospective data.At baseline, participants were aged 61±10 years; 52% men and 39%/13%/26%/22% Cauc/Chinese/Afr-Amer/Hispanic. Low sphericity was associated with higher Framingham CVD risk, greater coronary calcium score and higher N-terminal pro-brain natriuretic peptide (NT-proBNP); while increased sphericity was associated with higher NT-proBNP and lower ejection fraction. Low sphericity predicted incident CHD (HR: 1.48, 1.55-2.59 at ED) and CVD (HR: 1.82, 1.47-2.27 at ED). However, both low (HR: 1.81, 1.20-2.73 at ES) and high (HR: 2.21, 1.41-3.46 at ES) sphericity predicted incident HF. High sphericity also predicted AF.In a multiethnic population free of CVD at baseline, lowest sphericity was a predictor of incident CHD, CVD and HF over a 10-year follow-up period. Extreme sphericity was a strong predictor of incident HF and AF. SVI improved risk prediction models beyond established risk factors only for HF, but not for all CVD or CHD. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
BMJ Publishing Group |
en |
dc.relation.ispartofseries |
Heart |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Left ventricular shape predicts different types of cardiovascular events in the general population |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1136/heartjnl-2016-310052 |
en |
pubs.issue |
7 |
en |
pubs.begin-page |
499 |
en |
pubs.volume |
103 |
en |
dc.rights.holder |
Copyright: BMJ Publishing Group |
en |
dc.identifier.pmid |
27694110 |
en |
pubs.end-page |
507 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
542864 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
dc.identifier.eissn |
1468-201X |
en |
pubs.record-created-at-source-date |
2017-06-09 |
en |
pubs.dimensions-id |
27694110 |
en |