Incidence and predictors of oral feeding intolerance in acute pancreatitis: A systematic review, meta-analysis, and meta-regression.

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dc.contributor.author Bevan, MG en
dc.contributor.author Asrani, Varsha en
dc.contributor.author Bharmal, Sakina en
dc.contributor.author Wu, LM en
dc.contributor.author Windsor, John en
dc.contributor.author Petrov, Maxim en
dc.date.accessioned 2017-06-11T23:12:00Z en
dc.date.issued 2017-06 en
dc.identifier.citation Clinical Nutrition 36(3):722-729 Jun 2017 en
dc.identifier.issn 0261-5614 en
dc.identifier.uri http://hdl.handle.net/2292/33413 en
dc.description.abstract Tolerance of oral food is an important criterion for hospital discharge in patients with acute pancreatitis. Patients who develop oral feeding intolerance have prolonged hospitalisation, use additional healthcare resources, and have impaired quality of life. This study aimed to quantify the incidence of oral feeding intolerance, the effect of confounders, and determine the best predictors of oral feeding intolerance.Clinical studies indexed in three electronic databases (EMBASE, MEDLINE, and the Cochrane Central Register of Controlled Trials) were reviewed. Incidence and predictor data were meta-analysed and possible confounders were investigated by meta-regression analysis.A total of 22 studies with 2024 patients met the inclusion criteria, 17 of which (with 1550 patients) were suitable for meta-analysis. The incidence of oral feeding intolerance was 16.3%, and was not affected by WHO region, age, sex, or aetiology of acute pancreatitis. Nine of the 22 studies investigated a total of 62 different predictors of oral feeding intolerance. Serum lipase level prior to refeeding, pleural effusions, (peri)pancreatic collections, Ranson score, and Balthazar score were found to be statistically significant in meta-analyses.Oral feeding intolerance affects approximately 1 in 6 patients with acute pancreatitis. Serum lipase levels of more than 2.5 times the upper limit of normal prior to refeeding is a potentially useful threshold to identify patients at high risk of developing oral feeding intolerance. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher Elsevier Ltd and European Society for Clinical Nutrition and Metabolism en
dc.relation.ispartofseries Clinical Nutrition en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Incidence and predictors of oral feeding intolerance in acute pancreatitis: A systematic review, meta-analysis, and meta-regression. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.clnu.2016.06.006 en
pubs.issue 3 en
pubs.begin-page 722 en
pubs.volume 36 en
dc.rights.holder Copyright: Elsevier Ltd and European Society for Clinical Nutrition and Metabolism en
dc.identifier.pmid 27346178 en
pubs.end-page 729 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 534009 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1532-1983 en
pubs.record-created-at-source-date 2017-06-12 en
pubs.dimensions-id 27346178 en


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