dc.contributor.author |
McDonald, Elissa |
en |
dc.contributor.author |
Patel, Dipika |
en |
dc.contributor.author |
McGhee, Charles |
en |
dc.date.accessioned |
2017-06-14T02:50:01Z |
en |
dc.date.issued |
2015-03 |
en |
dc.identifier.citation |
Cornea 34(3):279-284 Mar 2015 |
en |
dc.identifier.issn |
0277-3740 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/33505 |
en |
dc.description.abstract |
PURPOSE: To identify the demographic and clinical associations of patients presenting with herpetic keratitis in New Zealand compared with presentations of presumed microbial keratitis. METHODS: A prospective, 6-month, observational case series of presumed microbial keratitis (including marginal keratitis), specifically identifying all cases of herpes simplex and varicella zoster keratitis attending an emergency eye clinic was conducted. Main outcome measures included demographics, presenting signs and symptoms, and medical, ocular, and drug history. RESULTS: A total of 140 cases of herpetic keratitis were identified, which comprised 125 cases of herpes simplex virus (89%) and 15 cases of varicella zoster virus (11%). Herpes simplex keratitis was associated with a history of keratitis (n = 58, phi = 0.24, P < 0.0001), Maori ethnicity (n = 27, phi = 0.26, P < 0.0001), respiratory disease (n = 18, phi = 0.14, P = 0.009), corticosteroid use (n = 23, phi = 0.22, P < 0.0001), and cardiovascular disease (CVD) (n = 10, phi = 0.11, P = 0.03). Inverse association was observed between herpes simplex keratitis and ocular surface disease (n = 8, phi = -0.16, P < 0.002) and Asian ethnicity (n = 4, phi = -0.11, P = 0.04). Varicella zoster keratitis was associated with CVD (n = 3, phi = 0.15, P = 0.03). CONCLUSIONS: Patients with asthma, CVD, on long-term corticosteroid inhalers or creams, or of Maori ethnicity need particular assessment to investigate herpes simplex as a possible cause of keratitis. Clinicians prescribing inhaled corticosteroids or topical corticosteroid creams should be aware of possible association with herpes simplex keratitis. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.publisher |
Lippincott Williams & Wilkins Ltd. |
en |
dc.relation.ispartofseries |
Cornea |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
Humans |
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dc.subject |
Herpesvirus 3, Human |
en |
dc.subject |
Keratitis, Herpetic |
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dc.subject |
Herpes Zoster Ophthalmicus |
en |
dc.subject |
Asthma |
en |
dc.subject |
Keratitis |
en |
dc.subject |
Cardiovascular Diseases |
en |
dc.subject |
Adrenal Cortex Hormones |
en |
dc.subject |
Risk Factors |
en |
dc.subject |
Prospective Studies |
en |
dc.subject |
Adult |
en |
dc.subject |
Aged |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Oceanic Ancestry Group |
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dc.subject |
New Zealand |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.title |
A prospective study of the clinical characteristics of patients with herpes simplex and varicella zoster keratitis, presenting to a New Zealand emergency eye clinic |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1097/ico.0000000000000338 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
279 |
en |
pubs.volume |
34 |
en |
dc.rights.holder |
Copyright: Lippincott Williams & Wilkins Ltd. |
en |
dc.identifier.pmid |
25532996 |
en |
pubs.end-page |
284 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
471688 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
dc.identifier.eissn |
1536-4798 |
en |
pubs.record-created-at-source-date |
2017-06-14 |
en |
pubs.dimensions-id |
25532996 |
en |