Modulation of cell adhesion to conductive polymers

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Show simple item record Malmstrom Pendred, Jenny en Hackett, Alissa en Feisst, Vaughan en Sejdic, JT en 2017-06-19T23:38:27Z en 2017 en
dc.identifier.citation International Journal of Nanotechnology 14(1-6):235-250 2017 en
dc.identifier.issn 1475-7435 en
dc.identifier.uri en
dc.description.abstract Our work on conductive polymer (CP) systems grafted with stimuli-responsive polymer brushes is motivated by the prospect of precisely controlling cellular behaviour by tailored smart interfaces. Here, the effects on cell adhesion by applying a potential to poly(3,4-ethylenedioxythiophene) (PEDOT) during both protein coating and cell culture is investigated. The results highlight the importance of pre-adsorbing fibronectin in this case, especially for the reduced polymer which binds protein strongly. The effects of changing the surface chemistry of the PEDOT electrode by grafting of brushes by atom transfer radical polymerisation (ATRP) is also investigated. Specifically, the composition of the salt-sensitive poly(oligo(ethylene glycol methyl ether methacrylate))-based brushes was tailored to control the level of cell adhesion to the interface. The composition, and also the length of the grafted brushes was seen to be important to the cell adhesion. It is also demonstrated how PEDOT films grafted with a protein and cell rejecting brush can be converted to a cell adhesive state by attaching an integrin ligand to the brush to mediate cell adhesion. en
dc.publisher Inderscience Publishers en
dc.relation.ispartofseries International Journal of Nanotechnology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Modulation of cell adhesion to conductive polymers en
dc.type Journal Article en
dc.identifier.doi 10.1504/IJNT.2017.082470 en
pubs.issue 1-6 en
pubs.begin-page 235 en
pubs.volume 14 en
dc.rights.holder Copyright: Inderscience Publishers en
pubs.end-page 250 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 617101 en Engineering en Chemical and Materials Eng en Libraries & Learning Services en Libraries & Learning Services en Research and Collections en Research and Collections en Research Services en Research Services en Science en Biological Sciences en Chemistry en
dc.identifier.eissn 1741-8151 en
pubs.record-created-at-source-date 2017-06-20 en

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