Diagnostic accuracy of Charcot's triad: a systematic review

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dc.contributor.author Rumsey, S en
dc.contributor.author Winders, J en
dc.contributor.author MacCormick, Andrew en
dc.date.accessioned 2017-06-20T21:58:28Z en
dc.date.issued 2017-04 en
dc.identifier.citation ANZ Journal of Surgery 87(4):232-238 Apr 2017 en
dc.identifier.issn 1445-1433 en
dc.identifier.uri http://hdl.handle.net/2292/33654 en
dc.description.abstract Charcot's triad is a well-established diagnostic tool for acute cholangitis (AC). It has been recognized as an inaccurate test in clinical practice; however, its exact sensitivity and specificity remain unclear. This knowledge is key to informing the value of its continued clinical application. The objectives of this study are to calculate an estimate of the sensitivity and specificity of Charcot's triad based on published research and consider its applicability to clinical practice and medical education.Electronic database search for relevant literature and review of reference lists of the subsequent articles for additional resources. Two independent researchers located articles which were qualitatively and quantitatively reviewed. The overall sensitivity and specificity values across all studies were subsequently calculated.The 16 articles included in the review varied widely in study design and the sensitivity of Charcot's triad was reported for AC. Across the included articles, there were 4288 patients studied. The overall sensitivity for Charcot's triad was calculated as 36.3%. The specificity was only analysed in three studies and had an overall value of 93.2%. Nine of the articles also investigated the sensitivity of Reynold's pentad which was consistently low with an overall value of 4.82%. The specificity of Reynold's pentad was not studied.Charcot's triad has limited clinical utility as a diagnostic algorithm for AC. It is an effective rule-in test but a poor rule-out test and should be applied and taught accordingly. A more sensitive diagnostic tool is required to achieve superior outcomes for AC patients. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher Blackwell Publishing Inc. en
dc.relation.ispartofseries ANZ Journal of Surgery en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Humans en
dc.subject Cholangitis en
dc.subject Acute Disease en
dc.subject Sensitivity and Specificity en
dc.subject Reproducibility of Results en
dc.subject Algorithms en
dc.title Diagnostic accuracy of Charcot's triad: a systematic review en
dc.type Journal Article en
dc.identifier.doi 10.1111/ans.13907 en
pubs.issue 4 en
pubs.begin-page 232 en
pubs.volume 87 en
dc.rights.holder Copyright: Blackwell Publishing Inc. en
dc.identifier.pmid 28213923 en
pubs.end-page 238 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.elements-id 614752 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
dc.identifier.eissn 1445-2197 en
pubs.record-created-at-source-date 2017-06-21 en
pubs.dimensions-id 28213923 en

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