Roadmap for cardiovascular circulation model

Show simple item record Safaei, Soroush en Bradley, Christopher en Suresh, Vinod en Mithraratne, Premakumar en Muller, A en Ho, Harvey en Ladd, D en Hellevik, LR en Omholt, SW en Chase, JG en Müller, LO en Watanabe, SM en Blanco, PJ en De Bono, Bernard en Hunter, Peter en 2017-06-21T02:16:49Z en 2016-12-01 en
dc.identifier.citation The Journal of Physiology 594(23):6909-6928 Dec 2016 en
dc.identifier.issn 1469-7793 en
dc.identifier.uri en
dc.description.abstract Computational models of many aspects of the mammalian cardiovascular circulation have been developed. Indeed, along with orthopaedics, this area of physiology is one that has attracted much interest from engineers, presumably because the equations governing blood flow in the vascular system are well understood and can be solved with well-established numerical techniques. Unfortunately, there have been only a few attempts to create a comprehensive public domain resource for cardiovascular researchers. In this paper we propose a roadmap for developing an open source cardiovascular circulation model. The model should be registered to the musculo-skeletal system. The computational infrastructure for the cardiovascular model should provide for near real-time computation of blood flow and pressure in all parts of the body. The model should deal with vascular beds in all tissues, and the computational infrastructure for the model should provide links into CellML models of cell function and tissue function. In this work we review the literature associated with 1D blood flow modelling in the cardiovascular system, discuss model encoding standards, software and a model repository. We then describe the coordinate systems used to define the vascular geometry, derive the equations and discuss the implementation of these coupled equations in the open source computational software OpenCMISS. Finally, some preliminary results are presented and plans outlined for the next steps in the development of the model, the computational software and the graphical user interface for accessing the model. en
dc.language eng en
dc.relation.ispartofseries The Journal of Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Roadmap for cardiovascular circulation model en
dc.type Journal Article en
dc.identifier.doi 10.1113/JP272660 en
pubs.issue 23 en
pubs.begin-page 6909 en
pubs.volume 594 en
dc.rights.holder Copyright: Blackwell Publishing Inc. en
dc.identifier.pmid 27506597 en
pubs.end-page 6928 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 539395 en Bioengineering Institute en ABI Associates en Engineering en Engineering Science en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1469-7793 en
pubs.number 23 en
pubs.record-created-at-source-date 2017-10-25 en 2016-09-29 en
pubs.dimensions-id 27506597 en

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