A novel computational sheep atria model for the study of atrial fibrillation

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dc.contributor.author Butters, TD en
dc.contributor.author Aslanidi, OV en
dc.contributor.author Zhao, Jichao en
dc.contributor.author Smaill, Bruce en
dc.contributor.author Zhang, H en
dc.date.accessioned 2017-06-28T01:29:58Z en
dc.date.issued 2013-04 en
dc.identifier.citation Interface Focus 3(2): 20120067 Apr 2013 en
dc.identifier.issn 2042-8901 en
dc.identifier.uri http://hdl.handle.net/2292/33805 en
dc.description.abstract Sheep are often used as animal models for experimental studies into the underlying mechanisms of cardiac arrhythmias. Previous studies have shown that biophysically detailed computer models of the heart provide a powerful alternative to experimental animal models for underpinning such mechanisms. In this study, we have developed a family of mathematical models for the electrical action potentials of various sheep atrial cell types. The developed cell models were then incorporated into a three-dimensional anatomical model of the sheep atria, which was recently reconstructed and segmented based on anatomical features within different regions. This created a novel biophysically detailed computational model of the three-dimensional sheep atria. Using the model, we then investigated the mechanisms by which paroxysmal rapid focal activity in the pulmonary veins can transit to sustained atrial fibrillation. It was found that the anisotropic property of the atria arising from the fibre structure plays an important role in facilitating the development of fibrillatory atrial excitation waves, and the electrical heterogeneity plays an important role in its initiation. en
dc.publisher Royal Society Publishing en
dc.relation.ispartofseries Interface Focus en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title A novel computational sheep atria model for the study of atrial fibrillation en
dc.type Journal Article en
dc.identifier.doi 10.1098/rsfs.2012.0067 en
pubs.issue 2 en
pubs.volume 3 en
dc.rights.holder Copyright: Royal Society Publishing en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 618800 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.number 20120067 en
pubs.record-created-at-source-date 2017-03-27 en
pubs.online-publication-date 2013-02-21 en

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