Cannabis and Stroke

Show simple item record Barber, Peter en
dc.contributor.editor Preedy, VR en 2017-06-28T04:42:08Z en 2017 en
dc.identifier.citation In Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Editors: Preedy VR. 486-493. Academic Press 2017 en
dc.identifier.citation en
dc.identifier.isbn 9780128007563 en
dc.identifier.uri en
dc.description.abstract It is likely that there is an association between cannabis and ischemic stroke and transient ischemic attack (TIA). There are multiple reports of mainly younger men, with no vascular risk factors other than tobacco and alcohol use, with symptom onset during or soon after cannabis use. This often follows a marked increase in cannabis intake. The strokes are mainly in the posterior circulation possibly reflecting a greater susceptibility to cannabis induced autonomic changes. Population based studies and retrospective audits have also found an association between ischemic stroke and TIA and cannabis. The numbers of patients using cannabis and presenting with stroke has been increasing in recent years and moves toward legalization for medical and recreational reasons will further increase these numbers. However, a causal association between cannabis and ischemic stroke has not been proven. One of the major confounding factors is tobacco, which is often smoked with cannabis. A causal link between cannabis and stroke is plausible, and a number of lines of evidence point to such a link. These include the temporal association between cannabis use and stroke, and recurrent stroke with cannabis reexposure. Cannabis is associated with myocardial infarction and atrial fibrillation. Myocardial infarction and atrial fibrillation both increase the risk of cardiac embolism, which in turn accounts for 20–25% of ischemic strokes. There is also a reversible cerebral cannabis arteriopathy with reversible vasoconstriction syndrome (RCVS), and (possibly) a more prolonged stenosis of cerebral arteries that has been called multifocal arterial stenosis (MIS). In this chapter, the evidence linking stroke and cannabis, and the lines of evidence pointing to a causal link, will be summarized. en
dc.description.uri en
dc.publisher Academic Press en
dc.relation.ispartof Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Medical en
dc.title Cannabis and Stroke en
dc.type Book Item en
dc.identifier.doi 10.1016/B978-0-12-800756-3.00059-4 en
pubs.begin-page 486 en
dc.rights.holder Copyright: Academic Press en en
pubs.end-page 493 en
dc.rights.accessrights en
pubs.elements-id 617915 en Medical and Health Sciences en School of Medicine en Medicine Department en
pubs.number 51 en
pubs.record-created-at-source-date 2017-03-21 en

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