dc.contributor.author |
Yarragudi, Sasi Bhushan |
en |
dc.contributor.author |
Richter, R |
en |
dc.contributor.author |
Lee, H |
en |
dc.contributor.author |
Walker, Greg |
en |
dc.contributor.author |
Clarkson, Andrew |
en |
dc.contributor.author |
Kumar, Haribalan |
en |
dc.contributor.author |
Rizwan, Sakila |
en |
dc.date.accessioned |
2017-06-29T00:04:06Z |
en |
dc.date.issued |
2017-05 |
en |
dc.identifier.issn |
0144-8617 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/33849 |
en |
dc.description.abstract |
Targeted delivery and retention of drug formulations in the olfactory mucosa, the target site for nose-to-brain drug absorption is a major challenge due to the geometrical complexity of the nose and nasal clearance. Recent modelling data indicates that 10μm-sized microparticles show maximum deposition in the olfactory mucosa. In the present study we tested the hypothesis that 10μm-sized mucoadhesive microparticles would preferentially deposit on, and increase retention of drug on, the olfactory mucosa in a novel 3D-printed human nasal-replica cast under simulated breathing. The naturally occurring mucoadhesive polymer, tamarind seed polysaccharide (TSP) was used to formulate the microparticles using a spray drying technique. Physicochemical properties of microparticles such as size, morphology and mucoadhesiveness was investigated using a combination of laser diffraction, electron microscopy and texture-analysis. Furthermore, FITC-dextrans (5-40kDa) were incorporated in TSP-microparticles as model drugs. Size-dependent permeability of the FITC-dextrans was observed ex vivo using porcine nasal mucosa. Using the human nasal-replica cast, greater deposition of 10μm TSP-microparticles in the olfactory region was observed compared to TSP-microparticles 2μm in size. Collectively, these findings support our hypothesis that 10μm-sized mucoadhesive microparticles can achieve selective deposition and retention of drug in the olfactory mucosa. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
Pergamon Press Ltd. |
en |
dc.relation.ispartofseries |
Carbohydrate Polymers |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.carbpol.2017.01.044 |
en |
pubs.begin-page |
216 |
en |
pubs.volume |
163 |
en |
dc.rights.holder |
Copyright: Pergamon Press Ltd. |
en |
dc.identifier.pmid |
28267500 |
en |
pubs.end-page |
226 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
612270 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Pharmacy |
en |
dc.identifier.eissn |
1879-1344 |
en |
pubs.record-created-at-source-date |
2017-06-29 |
en |
pubs.dimensions-id |
28267500 |
en |