Model-Based Interpretation of Skin Microstructural and Mechanical Measurements

Abstract

Accurate characterization of skin mechanics requires model-based interpretation of skin mechanical and structural measurements. Due to difficulties in measuring properties of in vivo skin, research efforts have focused largely on the characterization of in vitro skin. In this chapter, we review state-of-the-art constitutive models, with particular focus on structural models that can provide valuable insights into the relationship between tissue microstructure and mechanical response of skin. Constitutive parameter estimation remains a challenge and relies on the availability of a comprehensive range of deformation measurements of skin under various loading conditions. We provide a summary of current imaging techniques to visualize and quantify skin microstructure (such as collagen fiber organization) and instrumentation used for measuring the mechanical response of the skin. To enhance our understanding of skin mechanics, future research effort should focus on the integration of noninvasive in vivo imaging modalities, mechanical testing, and computational modeling.