Changes in the approach to acute diverticulitis

Show simple item record Jaung, Rebekah en Robertson, J en Vather, R en Rowbotham, D en Bissett, Ian en 2017-06-30T01:46:26Z en 2015-10 en
dc.identifier.citation ANZ Journal of Surgery 85(10):715-719 Oct 2015 en
dc.identifier.issn 1445-1433 en
dc.identifier.uri en
dc.description.abstract Acute diverticulitis (AD) is one of the most common acute admission diagnoses for general surgery, and its prevalence is increasing, in part due to the ageing population. Currently, most patients who present to a tertiary hospital are admitted for a period of treatment and observation. Simple, safe and cost-effective strategies for improving our current treatment of this condition will be invaluable in providing the most appropriate management for individual patients and for reducing the health resources expended on hospital admissions and parenteral antibiotics. AD can be categorized as uncomplicated or complicated, these two subtypes have a very different clinical course. The management of uncomplicated AD has become increasingly conservative, with a focus on symptomatic relief and supportive management. Recent research has brought into question the need for extended hospital admission and questioned the current use of antibiotics. Anti-inflammatory agents that reduce local inflammation in uncomplicated AD may be a useful means of reducing damage caused by inflammation and aiding earlier resolution of the inflammatory response and associated symptoms. Mesalazine is an anti-inflammatory agent that has been trialled in uncomplicated AD. Mesalazine has been shown to improve time to resolution of endoscopic and histological evidence of inflammation following an episode of AD and also reduce the rate of recurrence. In this literature review, we provide an overview of recent advances in AD classification, pathophysiology and management, and examine the possibility of introducing the use of anti-inflammatory agents in the management of uncomplicated AD. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher Blackwell Publishing Inc. en
dc.relation.ispartofseries ANZ Journal of Surgery en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Humans en
dc.subject Diverticulitis, Colonic en
dc.subject Acute Disease en
dc.subject Diverticulitis en
dc.subject Mesalamine en
dc.subject Anti-Inflammatory Agents en
dc.subject Anti-Bacterial Agents en
dc.subject Hospitalization en
dc.title Changes in the approach to acute diverticulitis en
dc.type Journal Article en
dc.identifier.doi 10.1111/ans.13233 en
pubs.issue 10 en
pubs.begin-page 715 en
pubs.volume 85 en
dc.rights.holder Copyright: Blackwell Publishing Inc. en
dc.identifier.pmid 26211943 en
pubs.end-page 719 en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 493069 en Medical and Health Sciences en School of Medicine en Surgery Department en
dc.identifier.eissn 1445-2197 en
pubs.record-created-at-source-date 2017-06-30 en
pubs.dimensions-id 26211943 en

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