dc.contributor.author |
Angeli, Timothy |
en |
dc.contributor.author |
O'Grady, Gregory |
en |
dc.contributor.author |
Du, Peng |
en |
dc.contributor.author |
Paskaranandavadivel, Niranchan |
en |
dc.contributor.author |
Pullan, AJ |
en |
dc.contributor.author |
Bissett, Ian |
en |
dc.contributor.author |
Cheng, Leo |
en |
dc.coverage.spatial |
England |
en |
dc.date.accessioned |
2017-07-02T21:14:06Z |
en |
dc.date.issued |
2013-05 |
en |
dc.identifier.citation |
Neurogastroenterology and Motility 25(5):e304-e314 May 2013 |
en |
dc.identifier.issn |
1350-1925 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/33916 |
en |
dc.description.abstract |
BACKGROUND: Slow-waves modulate the pattern of small intestine contractions. However, the large-scale spatial organization of intestinal slow-wave pacesetting remains uncertain because most previous studies have had limited resolution. This study applied high-resolution (HR) mapping to evaluate intestinal pacesetting mechanisms and propagation patterns in vivo. METHODS: HR serosal mapping was performed in anesthetized pigs using flexible arrays (256 electrodes; 32 × 8; 4 mm spacing), applied along the jejunum. Slow-wave propagation patterns, frequencies, and velocities were calculated. Slow-wave initiation sources were identified and analyzed by animation and isochronal activation mapping. KEY RESULTS: Analysis comprised 32 recordings from nine pigs (mean duration 5.1 ± 3.9 min). Slow-wave propagation was analyzed, and a total of 26 sources of slow-wave initiation were observed and classified as focal pacemakers (31%), sites of functional re-entry (23%) and circumferential re-entry (35%), or indeterminate sources (11%). The mean frequencies of circumferential and functional re-entry were similar (17.0 ± 0.3 vs 17.2 ± 0.4 cycle min(-1) ; P = 0.5), and greater than that of focal pacemakers (12.7 ± 0.8 cycle min(-1) ; P < 0.001). Velocity was anisotropic (12.9 ± 0.7 mm s(-1) circumferential vs 9.0 ± 0.7 mm s(-1) longitudinal; P < 0.05), contributing to the onset and maintenance of re-entry. CONCLUSIONS & INFERENCES: This study has shown multiple patterns of slow-wave initiation in the jejunum of anesthetized pigs. These results constitute the first description and analysis of circumferential re-entry in the gastrointestinal tract and functional re-entry in the in vivo small intestine. Re-entry can control the direction, pattern, and frequency of slow-wave propagation, and its occurrence and functional significance merit further investigation. |
en |
dc.language |
eng |
en |
dc.publisher |
Blackwell Publishing Inc. |
en |
dc.relation.ispartofseries |
Neurogastroenterology and Motility |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Animals |
en |
dc.subject |
Electrophysiology |
en |
dc.subject |
Interstitial Cells of Cajal |
en |
dc.subject |
Intestine, Small |
en |
dc.subject |
Myoelectric Complex, Migrating |
en |
dc.subject |
Signal Processing, Computer-Assisted |
en |
dc.subject |
Swine |
en |
dc.title |
Circumferential and functional re-entry of in vivo slow-wave activity in the porcine small intestine |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/nmo.12085 |
en |
pubs.issue |
5 |
en |
pubs.begin-page |
e304 |
en |
pubs.volume |
25 |
en |
dc.rights.holder |
Copyright: Blackwell Publishing Inc. |
en |
dc.identifier.pmid |
23489929 |
en |
pubs.end-page |
e314 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
374454 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Surgery Department |
en |
dc.identifier.eissn |
1365-2982 |
en |
pubs.record-created-at-source-date |
2017-07-03 |
en |
pubs.dimensions-id |
23489929 |
en |