dc.contributor.author |
Fischer, MA |
en |
dc.contributor.author |
Raptis, DA |
en |
dc.contributor.author |
Donati, OF |
en |
dc.contributor.author |
Hunziker, R |
en |
dc.contributor.author |
Schade, E |
en |
dc.contributor.author |
Sotiropoulos, GC |
en |
dc.contributor.author |
McCall, J |
en |
dc.contributor.author |
Bartlett, Adam |
en |
dc.contributor.author |
Bachellier, P |
en |
dc.contributor.author |
Frilling, A |
en |
dc.contributor.author |
Breitenstein, S |
en |
dc.contributor.author |
Clavien, P-A |
en |
dc.contributor.author |
Alkadhi, H |
en |
dc.contributor.author |
Patak, MA |
en |
dc.date.accessioned |
2017-07-02T21:48:17Z |
en |
dc.date.available |
2015-06-28 |
en |
dc.date.issued |
2015-10 |
en |
dc.identifier.citation |
European Journal of Radiology, October 2015, 84 (10), 1879 - 1887 |
en |
dc.identifier.issn |
0720-048X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/33920 |
en |
dc.description.abstract |
To determine MR-imaging features for the differentiation between hepatocellular carcinoma (HCC) and benign hepatocellular tumors in the non-cirrhotic liver.107 consecutive patients without liver cirrhosis (46 male; 45 ± 14 years) who underwent liver resection due to suspicion of HCC were included in this multi-center study. The following imaging features were assessed: lesion diameter and demarcation, satellite-lesions, central-scar, capsule, fat-content, hemorrhage, vein-infiltration and signal-intensity (SI) on native T1-, T2- and dynamic-enhanced T1-weighted images (center versus periphery). In addition, contrast-media (CM) uptake in the liver specific phase was analyzed in a sub-group of 42 patients.Significant differences between HCC (n=55) and benign lesions (n=52) were shown for native T1-, T2- and dynamic-enhanced T1-SI, fat-content, and satellite-lesions (all, P<.05). Independent predictors for HCC were T1-hypointensity (odds-ratio, 4.81), T2-hypo-/hyperintensity (5.07), lack of central tumor-enhancement (3.36), and satellite-lesions (5.78; all P<0.05). Sensitivity and specificity of HCC was 91% and 75% respectively for two out-of four independent predictors, whereas specificity reached 98% for all four predictors. Sub-analysis, showed significant differences in liver specific CM uptake between HCC (n=18) and benign lesions (n=24; P<0.001) and revealed lack of liver specific CM uptake (odds-ratio, 2.7) as additional independent feature for diagnosis of HCC.Independent MRI features indicating HCC are T1-hypointensity, T2-hypo- or hyperintensity, lack of central tumor-enhancement, presence of satellite-lesions and lack of liver specific CM-uptake. These features may have the potential to improve the diagnosis of HCC in the non-cirrhotic liver. |
en |
dc.description.uri |
https://www.ncbi.nlm.nih.gov/pubmed/26194029 |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
English |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
European Journal of Radiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0720-048X/
https://www.elsevier.com/about/our-business/policies/sharing |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Liver |
en |
dc.subject |
Humans |
en |
dc.subject |
Hepatitis C |
en |
dc.subject |
Adenoma, Liver Cell |
en |
dc.subject |
Carcinoma, Hepatocellular |
en |
dc.subject |
Liver Neoplasms |
en |
dc.subject |
Focal Nodular Hyperplasia |
en |
dc.subject |
Gadolinium DTPA |
en |
dc.subject |
Contrast Media |
en |
dc.subject |
Diagnosis, Differential |
en |
dc.subject |
Magnetic Resonance Imaging |
en |
dc.subject |
Image Enhancement |
en |
dc.subject |
Hepatectomy |
en |
dc.subject |
Sensitivity and Specificity |
en |
dc.subject |
Retrospective Studies |
en |
dc.subject |
Follow-Up Studies |
en |
dc.subject |
Adult |
en |
dc.subject |
Aged |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.title |
MR imaging features for improved diagnosis of hepatocellular carcinoma in the non-cirrhotic liver: Multi-center evaluation |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.ejrad.2015.06.029 |
en |
pubs.issue |
10 |
en |
pubs.begin-page |
1879 |
en |
pubs.volume |
84 |
en |
dc.identifier.pmid |
26194029 |
en |
pubs.author-url |
http://www.sciencedirect.com/science/article/pii/S0720048X15300383?via=ihub |
en |
pubs.end-page |
1887 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
492649 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Surgery Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1872-7727 |
en |
pubs.record-created-at-source-date |
2017-07-03 |
en |
pubs.online-publication-date |
2015-07-02 |
en |
pubs.dimensions-id |
26194029 |
en |