Importance of serrated polyps in colorectal carcinogenesis

Show simple item record Liang, JJ en Bissett, Ian en Kalady, M en Bennet, A en Church, JM en 2017-07-02T22:05:24Z en 2013-05 en
dc.identifier.citation ANZ Journal of Surgery 83(5):325-330 May 2013 en
dc.identifier.issn 1445-1433 en
dc.identifier.uri en
dc.description.abstract Colorectal cancer is an invasive neoplasm of the glandular epithelium of the colon and rectum that begins in a precursor lesion and expands to replace its lesion of origin. The majority of colorectal cancers arise from an adenoma, and the ‘adenoma to carcinoma’ pathway has been acknowledged for decades. More recently, another precursor lesion has been recognized: the serrated polyp. Serrated polyps are characterized by a sawtooth appearance of the crypt epithelium resulting from failure of apoptosis and a build-up of aging colonocytes. Although initially felt to be innocent of involvement in colorectal carcinogenesis, some types of serrated polyp are being increasingly recognized as precursor lesions, prone to develop into cancer, and likely to be a cause of ‘missed’ or interval cancers after colonoscopic screening. It is essential that gastrointestinal specialists appreciate the clinical significance of these lesions and what that means for colorectal cancer screening, and prevention. The purpose of this review is to highlight the importance serrated lesions of the colon and rectum, and to summarize current opinion on their natural history, diagnosis, surveillance and treatment. en
dc.publisher Blackwell Publishing Inc. en
dc.relation.ispartofseries ANZ Journal of Surgery en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Importance of serrated polyps in colorectal carcinogenesis en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1445-2197.2012.06269.x en
pubs.issue 5 en
pubs.begin-page 325 en
pubs.volume 83 en
dc.rights.holder Copyright: Blackwell Publishing Inc. en
dc.identifier.pmid 23078414 en
pubs.end-page 330 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 489255 en Medical and Health Sciences en School of Medicine en Surgery Department en
dc.identifier.eissn 1445-2197 en
pubs.record-created-at-source-date 2017-07-03 en
pubs.dimensions-id 23078414 en

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