Modeling the hepatic arterial buffer response in the liver

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Show simple item record Ho, Harvey en Sorrell, K en Bartlett, Adam en Hunter, Peter en 2017-07-04T00:50:13Z en 2012-01-29 en 2013-08 en
dc.identifier.citation Medical Engineering and Physics, August 2013, 35 (8), 1053 - 1058 en
dc.identifier.issn 1350-4533 en
dc.identifier.uri en
dc.description.abstract In this paper we present an electrical analog model for the hepatic arterial buffer response (HABR), an intrinsic regulation mechanism in the liver whereby the arterial flow counteracts the changes in portal venous flow. The model itself is a substantial simplification of a previously published model, with nonlinear arterial and portal resistors introduced to account for the dynamic HABR effects. We calibrate the baseline model using published hemodynamic data, and then perform a virtual portal occlusion simulation where the portal vein is half or fully occluded. The simulation results, which suggest that the increased arterial flow cannot fully compensate lost portal perfusion, are consistent with clinical reports and animal model findings. Since HABR functions in both the whole liver and liver graft after transplantation, we also simulate blood flow in a virtual right-lobe graft by adjusting the electronic component parameters in the electric circuit, and our model is able to reproduce the portal venous hyperperfusion and hepatic arterial hypoperfusion conditions due to the HABR effects. en
dc.description.uri en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries Medical Engineering and Physics en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Modeling the hepatic arterial buffer response in the liver en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.medengphy.2012.10.008 en
pubs.issue 8 en
pubs.begin-page 1053 en
pubs.volume 35 en
dc.identifier.pmid 23157977 en en
pubs.end-page 1058 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 364354 en Bioengineering Institute en ABI Associates en Medical and Health Sciences en School of Medicine en Surgery Department en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1873-4030 en
pubs.record-created-at-source-date 2017-07-04 en 2012-11-15 en
pubs.dimensions-id 23157977 en

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