dc.contributor.author |
Lee, C |
en |
dc.contributor.author |
Vather, R |
en |
dc.contributor.author |
O'Callaghan, Anne |
en |
dc.contributor.author |
Robinson, Jacqualine |
en |
dc.contributor.author |
McLeod, B |
en |
dc.contributor.author |
Findlay, Michael |
en |
dc.contributor.author |
Bissett, Ian |
en |
dc.date.accessioned |
2017-07-06T23:38:11Z |
en |
dc.date.issued |
2013 |
en |
dc.identifier.citation |
American Journal of Hospice and Palliative Care 30(8):752-758 2013 |
en |
dc.identifier.issn |
1049-9091 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/34067 |
en |
dc.description.abstract |
Malignant bowel obstruction (MBO) is common in patients with advanced cancer.To perform a phase II study to assess the feasibility of conducting a phase III trial investigating the therapeutic value of gastrografin in MBO.Randomized double-blinded placebo-controlled feasibility study. Participants received 100 mL of either gastrografin or placebo.Over 8 months, 57 patients were screened and 9 enrolled (15.8% recruitment rate). Of the 9 enrolled, 4 received gastrografin (with 2 completing assessment) and 5 received placebo (with 4 completing assessment).It is not feasible to conduct a phase III trial using the same study protocol. This study validates the use of the phase II feasibility study to assess protocol viability in a palliative population prior to embarking on a larger trial. |
en |
dc.publisher |
SAGE Publications |
en |
dc.relation.ispartofseries |
American Journal of Hospice and Palliative Care |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Validation of the phase II feasibility study in a palliative care setting: gastrografin in malignant bowel obstruction |
en |
dc.type |
Journal Article |
en |
pubs.issue |
8 |
en |
pubs.begin-page |
752 |
en |
pubs.volume |
30 |
en |
dc.rights.holder |
Copyright: SAGE Publications |
en |
dc.identifier.pmid |
23277632 |
en |
pubs.end-page |
758 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
457886 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Oncology |
en |
pubs.org-id |
Nursing |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Psychological Medicine Dept |
en |
pubs.org-id |
Surgery Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1938-2715 |
en |
pubs.record-created-at-source-date |
2015-07-01 |
en |
pubs.online-publication-date |
2012-12-31 |
en |
pubs.dimensions-id |
23277632 |
en |