dc.contributor.author |
Hanif, Muhammad |
en |
dc.contributor.author |
Meier, SM |
en |
dc.contributor.author |
Adhireksan, Z |
en |
dc.contributor.author |
Henke, H |
en |
dc.contributor.author |
Martic, S |
en |
dc.contributor.author |
Movassaghi, S |
en |
dc.contributor.author |
Labib, M |
en |
dc.contributor.author |
Kandioller, W |
en |
dc.contributor.author |
Jamieson, Stephen |
en |
dc.contributor.author |
Hejl, M |
en |
dc.contributor.author |
Jakupec, MA |
en |
dc.contributor.author |
Kraatz, H-B |
en |
dc.contributor.author |
Davey, CA |
en |
dc.contributor.author |
Keppler, BK |
en |
dc.contributor.author |
Hartinger, Christian |
en |
dc.date.accessioned |
2017-07-12T00:32:10Z |
en |
dc.date.issued |
2017-06 |
en |
dc.identifier.citation |
ChemPlusChem 82(6):841-847 Jun 2017 |
en |
dc.identifier.issn |
2192-6506 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/34177 |
en |
dc.description.abstract |
Hydroxypyr(id)ones constitute an emerging platform for the design of drug molecules, owing to their favorable biocompatibility and toxicity profiles. Herein, [RuII(η6-p-cymene)] complexes with 3-hydroxy-2-pyridinone functionalized with morpholine and thiomorpholine, as a means often used in medicinal chemistry to alter the physicochemical properties of drug compounds, are reported. The compounds underwent hydrolysis of the Ru−Cl bond and the aqua species were stable for up to 48 h in aqueous solution, as observed by 1H NMR spectroscopy and ESI-MS. The compounds formed adducts with amino acids and proteins through cleavage of the pyridinone ligand. Binding experiments to the nucleosome core particle by means of X-ray crystallography revealed similar reactivity and exclusive binding to histidine moieties of the histone proteins. Preliminary cyclin-dependent kinase 2 (CDK2)/cyclin A kinase inhibitory studies revealed promising activity similar to that of structurally related organometallic compounds. |
en |
dc.publisher |
Wiley-VCH Verlag |
en |
dc.relation.ispartofseries |
ChemPlusChem |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Functionalization of Ruthenium(II)(η 6 - p -cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/cplu.201700050 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
841 |
en |
pubs.volume |
82 |
en |
dc.rights.holder |
Copyright: Wiley-VCH Verlag |
en |
pubs.end-page |
847 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
618902 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
2192-6506 |
en |
pubs.record-created-at-source-date |
2017-07-12 |
en |
pubs.dimensions-id |
31961568 |
en |