The immunohistochemical distribution of the GABAA receptor α1, α2, α3, β2/3 and γ2 subunits in the human thalamus

Show simple item record Waldvogel, Henry en Munkle, M en van Roon-Mom, W en Mohler, H en Faull, Richard en 2017-07-20T02:07:57Z en 2017-07 en
dc.identifier.citation Journal of Chemical Neuroanatomy 82:39-55 Jul 2017 en
dc.identifier.issn 0891-0618 en
dc.identifier.uri en
dc.description.abstract The GABAA receptor is the most abundant inhibitory receptor in the human brain and is assembled from a variety of different subunit subtypes which determines their pharmacology and physiology. To determine which GABAA receptor subunit proteins are found in the human thalamus we investigated the distribution of five major GABAA receptor subunits α1, α2, α3, β2,3 and γ2 using immunohistochemical techniques. The α1-, β2,3- and γ2- subunits which combine to form a benzodiazepine sensitive GABAA receptor showed the most intense levels of staining and were the most common subunits found throughout the human thalamus especially in the ventral and posterior nuclear groups. The next most intense staining was for the α3-subunit followed by the α2-subunit. The intralaminar nuclear group, the mediodorsal nucleus and the thalamic reticular nucleus contained α1-, β2,3- and γ2- subunits staining as well as the highest levels of the α2- and α3- subunits. The sensory dorsal lateral geniculate nucleus contained very high levels of α1- and β2,3- and γ2-subunits. The highest densities of GABAA receptors found throughout the thalamus which contained the subunits α1, β2,3, and γ2 included nuclei which are especially involved in the control or the modulation of the cortico-basal ganglia-thalamo-cortical motor circuits and are thus important in disorders such as Huntington's disease where the GABAergic projections of the basal ganglia are compromised. In addition the majority of receptors in the thalamic reticular nucleus contain α3 and γ2 subunits whilst the intralaminar nuclei contain high levels of α2 and α3 subunits. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher Elsevier BV en
dc.relation.ispartofseries Journal of Chemical Neuroanatomy en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title The immunohistochemical distribution of the GABAA receptor α1, α2, α3, β2/3 and γ2 subunits in the human thalamus en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.jchemneu.2017.04.006 en
pubs.begin-page 39 en
pubs.volume 82 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 28445782 en
pubs.end-page 55 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 623787 en Medical and Health Sciences en Medical Sciences en Anatomy and Medical Imaging en
dc.identifier.eissn 1873-6300 en
pubs.record-created-at-source-date 2017-07-20 en
pubs.dimensions-id 28445782 en

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