Biologically Active Acetylenic Amino Alcohol and N-Hydroxylated 1,2,3,4-Tetrahydro-β-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum

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dc.contributor.author Wang, J en
dc.contributor.author Pearce, Allison en
dc.contributor.author Chan, STS en
dc.contributor.author Taylor, Richard en
dc.contributor.author Page, MJ en
dc.contributor.author Valentin, A en
dc.contributor.author Bourguet-Kondracki, M-L en
dc.contributor.author Dalton, James en
dc.contributor.author Wiles, Siouxsie en
dc.contributor.author Copp, Brent en
dc.date.accessioned 2017-07-25T23:52:09Z en
dc.date.issued 2016-03 en
dc.identifier.citation Journal of Natural Products, 79(3):607-610, Mar 2016 en
dc.identifier.issn 0163-3864 en
dc.identifier.uri http://hdl.handle.net/2292/34505 en
dc.description.abstract The first occurrence of an acetylenic 1-amino-2-alcohol, distaminolyne A (1), isolated from the New Zealand ascidian Pseudodistoma opacum, is reported. The isolation and structure elucidation of 1 and assignment of absolute configuration using the exciton coupled circular dichroism technique are described. In addition, a new N-9 hydroxy analogue (2) of the known P. opacum metabolite 7-bromohomotrypargine is also reported. Antimicrobial screening identified modest activity of 1 toward Escherichia coli, Staphylococcus aureus, and Mycobacterim tuberculosis, while 2 exhibited a moderate antimalarial activity (IC50 3.82 μM) toward a chloroquine-resistant strain (FcB1) of Plasmodium falciparum. en
dc.format.medium Print-Electronic en
dc.language English en
dc.publisher American Chemical Society en
dc.relation.ispartofseries Journal of Natural Products en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0163-3864/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Animals en
dc.subject Urochordata en
dc.subject Plasmodium falciparum en
dc.subject Escherichia coli en
dc.subject Mycobacterium tuberculosis en
dc.subject Staphylococcus aureus en
dc.subject Alkynes en
dc.subject Carbolines en
dc.subject Chloroquine en
dc.subject Antimalarials en
dc.subject Microbial Sensitivity Tests en
dc.subject Inhibitory Concentration 50 en
dc.subject Drug Resistance, Bacterial en
dc.subject Molecular Structure en
dc.subject New Zealand en
dc.title Biologically Active Acetylenic Amino Alcohol and N-Hydroxylated 1,2,3,4-Tetrahydro-β-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum en
dc.type Journal Article en
dc.identifier.doi 10.1021/acs.jnatprod.5b00770 en
pubs.issue 3 en
pubs.begin-page 607 en
pubs.volume 79 en
dc.identifier.pmid 26670413 en
pubs.author-url http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.5b00770 en
pubs.end-page 610 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 515054 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Molecular Medicine en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.org-id Marine Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1520-6025 en
pubs.record-created-at-source-date 2017-07-26 en
pubs.dimensions-id 26670413 en


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