dc.contributor.author |
Wang, J |
en |
dc.contributor.author |
Pearce, Allison |
en |
dc.contributor.author |
Chan, STS |
en |
dc.contributor.author |
Taylor, Richard |
en |
dc.contributor.author |
Page, MJ |
en |
dc.contributor.author |
Valentin, A |
en |
dc.contributor.author |
Bourguet-Kondracki, M-L |
en |
dc.contributor.author |
Dalton, James |
en |
dc.contributor.author |
Wiles, Siouxsie |
en |
dc.contributor.author |
Copp, Brent |
en |
dc.date.accessioned |
2017-07-25T23:52:09Z |
en |
dc.date.issued |
2016-03 |
en |
dc.identifier.citation |
Journal of Natural Products, 79(3):607-610, Mar 2016 |
en |
dc.identifier.issn |
0163-3864 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/34505 |
en |
dc.description.abstract |
The first occurrence of an acetylenic 1-amino-2-alcohol, distaminolyne A (1), isolated from the New Zealand ascidian Pseudodistoma opacum, is reported. The isolation and structure elucidation of 1 and assignment of absolute configuration using the exciton coupled circular dichroism technique are described. In addition, a new N-9 hydroxy analogue (2) of the known P. opacum metabolite 7-bromohomotrypargine is also reported. Antimicrobial screening identified modest activity of 1 toward Escherichia coli, Staphylococcus aureus, and Mycobacterim tuberculosis, while 2 exhibited a moderate antimalarial activity (IC50 3.82 μM) toward a chloroquine-resistant strain (FcB1) of Plasmodium falciparum. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
English |
en |
dc.publisher |
American Chemical Society |
en |
dc.relation.ispartofseries |
Journal of Natural Products |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0163-3864/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Animals |
en |
dc.subject |
Urochordata |
en |
dc.subject |
Plasmodium falciparum |
en |
dc.subject |
Escherichia coli |
en |
dc.subject |
Mycobacterium tuberculosis |
en |
dc.subject |
Staphylococcus aureus |
en |
dc.subject |
Alkynes |
en |
dc.subject |
Carbolines |
en |
dc.subject |
Chloroquine |
en |
dc.subject |
Antimalarials |
en |
dc.subject |
Microbial Sensitivity Tests |
en |
dc.subject |
Inhibitory Concentration 50 |
en |
dc.subject |
Drug Resistance, Bacterial |
en |
dc.subject |
Molecular Structure |
en |
dc.subject |
New Zealand |
en |
dc.title |
Biologically Active Acetylenic Amino Alcohol and N-Hydroxylated 1,2,3,4-Tetrahydro-β-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1021/acs.jnatprod.5b00770 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
607 |
en |
pubs.volume |
79 |
en |
dc.identifier.pmid |
26670413 |
en |
pubs.author-url |
http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.5b00770 |
en |
pubs.end-page |
610 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
515054 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Chemistry |
en |
pubs.org-id |
Marine Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1520-6025 |
en |
pubs.record-created-at-source-date |
2017-07-26 |
en |
pubs.dimensions-id |
26670413 |
en |