dc.contributor.author |
Rueb, K |
en |
dc.contributor.author |
Mynard, J |
en |
dc.contributor.author |
Liu, R |
en |
dc.contributor.author |
Wake, Melissa |
en |
dc.contributor.author |
Vuillermin, P |
en |
dc.contributor.author |
Ponsonby, A-L |
en |
dc.contributor.author |
Zannino, D |
en |
dc.contributor.author |
Burgner, DP |
en |
dc.date.accessioned |
2017-07-31T00:17:21Z |
en |
dc.date.available |
2017-02-20 |
en |
dc.date.issued |
2017-07 |
en |
dc.identifier.citation |
VASA, 46(4):275-281 Jul 2017 |
en |
dc.identifier.issn |
0301-1526 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/34602 |
en |
dc.description.abstract |
Carotid intima-media thickness (CIMT), an ultrasonographic marker of cardiovascular risk, is increasingly used in adults and children. The choice of specific images used to quantify CIMT from a cine sequence is often based on image quality rather than on a consistent point in the cardiac cycle. This methodological study quantified the imprecision that may be introduced by variation of CIMT during the cardiac cycle.Data from four-year-olds, 11 to 12-year-olds, and adults (n=30 each age group) were selected retrospectively from two population-derived studies. Far wall CIMT of the right common carotid artery was measured at end-diastole and peak systole using standardized protocols. All images were analysed using semi-automated edge-detection software.In all age groups CIMT varied significantly during the cardiac cycle and was largest at end-diastole. The mean difference in CIMT between end-diastole and peak systole was greater in four-year-olds (38 μm; 95 % confidence interval (CI) 33 to 43 μm) and 11 to 12-year-olds (31 μm; CI 26 to 36 μm) than in adults (18 μm; CI 16 to 22 μm). Carotid IMT increased by 8.8 % (CI 7.7 to 9.8 %), 6.9 % (CI 5.8 to 8.1 %), and 3.8 % (CI 3.1 to 4.5 %) between minimum and maximum arterial diameter in four-year-olds, 11 to 12-year-olds, and adults, respectively. The greatest variation in CIMT during the cardiac cycle was observed in children (up to 14 %).Inconsistent timing of CIMT measurement during the cardiac cycle is an avoidable source of imprecision, especially in children, in whom inter-individual differences are smallest. As CIMT is largest at end-diastole, this is the most appropriate time point for consistent and comparable measurements to be made. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
English |
en |
dc.publisher |
Hans Huber AG |
en |
dc.relation.ispartofseries |
VASA |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0301-1526/
https://us.hogrefe.com/service/for-authors/for-journal-authors/guidelines-on-sharing-and-use-of-articles-in-hogrefe-journals |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Changes in carotid artery intima-media thickness during the cardiac cycle - a comparative study in early childhood, mid-childhood, and adulthood |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1024/0301-1526/a000630 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
275 |
en |
pubs.volume |
46 |
en |
dc.identifier.pmid |
28332441 |
en |
pubs.author-url |
http://econtent.hogrefe.com/doi/pdf/10.1024/0301-1526/a000630 |
en |
pubs.end-page |
281 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
621632 |
en |
dc.identifier.eissn |
1664-2872 |
en |
pubs.record-created-at-source-date |
2017-07-31 |
en |
pubs.online-publication-date |
2017-03-23 |
en |
pubs.dimensions-id |
28332441 |
en |