dc.contributor.author |
Wang, Michael |
en |
dc.contributor.author |
Ganesalingam, K |
en |
dc.contributor.author |
Loh, CS |
en |
dc.contributor.author |
Alberquerque, T |
en |
dc.contributor.author |
Al-Kanani, S |
en |
dc.contributor.author |
Misra, Stuti |
en |
dc.contributor.author |
Craig, Jennifer |
en |
dc.date.accessioned |
2017-08-07T02:37:05Z |
en |
dc.date.available |
2016-11-05 |
en |
dc.date.issued |
2017-02 |
en |
dc.identifier.citation |
Contact Lens and Anterior Eye, 40(1):53-58 Feb 2017 |
en |
dc.identifier.issn |
1367-0484 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/34857 |
en |
dc.description.abstract |
To assess the effects of two weeks of regular phospholipid liposomal spray application on lipid layer grade, tear film stability, subjective comfort, visual acuity, and lipid deposition in silicone hydrogel contact lens wearers.Thirty-one existing contact lens wearers were enrolled and fitted with two week planned replacement silicone hydrogel contact lenses (Acuvue® Oasys®) in a prospective, randomized, paired-eye, investigator-masked trial. A phospholipid liposomal spray (Tears Again®) was applied to one eye (randomized) four times daily for two weeks. LogMAR high contrast visual acuity (VA), low contrast glare acuity (LCGA), non-invasive tear film break-up time (NIBUT), and lipid layer grade (LLG) were measured at baseline and day 14, in both treated and control eyes. Subjective comfort relative to baseline, and spectrofluorophotometric assessment of contact lens surface lipid deposition were also assessed on day 14.All measurements did not differ at baseline between treated and control eyes. Lipid layer thickness and tear film stability were increased on day 14 in treated eyes (all p<0.05), but not in control eyes (all p>0.05). A greater proportion of participants reported improved comfort in the treated eye relative to the control eye (p=0.002). There were no significant differences in visual acuity or in contact lens surface lipid deposition, between treated and control eyes, on day 14 (all p>0.05).The phospholipid liposomal spray increased tear film stability, lipid layer thickness and subjective comfort in silicone hydrogel contact lens wearers, without adversely affecting visual acuity or contact lens surface lipid deposition. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
English |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Contact Lens and Anterior Eye |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/1367-0484/
https://www.elsevier.com/about/our-business/policies/sharing |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Tears |
en |
dc.subject |
Humans |
en |
dc.subject |
Silicone Gels |
en |
dc.subject |
Phospholipids |
en |
dc.subject |
Biocompatible Materials |
en |
dc.subject |
Liposomes |
en |
dc.subject |
Aerosols |
en |
dc.subject |
Equipment Design |
en |
dc.subject |
Equipment Failure Analysis |
en |
dc.subject |
Materials Testing |
en |
dc.subject |
Contact Lenses, Hydrophilic |
en |
dc.subject |
Visual Acuity |
en |
dc.subject |
Adsorption |
en |
dc.subject |
Surface Properties |
en |
dc.subject |
Adolescent |
en |
dc.subject |
Adult |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Young Adult |
en |
dc.title |
Compatibility of phospholipid liposomal spray with silicone hydrogel contact lens wear |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.clae.2016.11.002 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
53 |
en |
pubs.volume |
40 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
27908604 |
en |
pubs.author-url |
http://www.sciencedirect.com/science/article/pii/S1367048416301618 |
en |
pubs.end-page |
58 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
552258 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
dc.identifier.eissn |
1476-5411 |
en |
pubs.record-created-at-source-date |
2017-08-07 |
en |
pubs.online-publication-date |
2016-11-28 |
en |
pubs.dimensions-id |
27908604 |
en |