Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission

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dc.contributor.author Murphy, Rinki en
dc.contributor.author Tsai, Peter en
dc.contributor.author Jullig, Maria en
dc.contributor.author Liu, Amy en
dc.contributor.author Plank, Lindsay en
dc.contributor.author Booth, M en
dc.date.accessioned 2017-08-10T04:26:00Z en
dc.date.issued 2017-04 en
dc.identifier.citation Obesity Surgery 27(4):917-925 Apr 2017 en
dc.identifier.issn 0960-8923 en
dc.identifier.uri http://hdl.handle.net/2292/34989 en
dc.description.abstract It is unclear whether specific gut microbiota is associated with remission of type 2 diabetes (T2D) after distinct types of bariatric surgery.The aim of this study is to examine gut microbiota changes after laparoscopic Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgery in obese patients with T2D.Whole-metagenome shotgun sequencing of DNA fragments using Illumina HiSeq2000 was obtained from stool samples collected from 14 obese T2D patients pre-operatively (while on very low calorie diet) and 1 year after randomisation to laparoscopic SG (n = 7) or RYGB (n = 7). Resulting shotgun reads were annotated with Kyoto Encyclopedia of Genes and Genomes (KEGG).Body weight reduction and dietary change was similar 1 year after both surgery types. Identical proportions (n = 5/7) achieved diabetes remission (HbA1c < 48 mmol/mol without medications) 1 year after RYGB and SG. RYGB resulted in increased Firmicutes and Actinobacteria phyla but decreased Bacteroidetes phyla. SG resulted in increased Bacteroidetes phyla. Only an increase in Roseburia species was observed among those achieving diabetes remission, common to both surgery types. KEGG Orthology and pathway analysis predicted contrasting and greater gut microbiota metabolism changes after diabetes remission following RYGB than after SG. Those with persistent diabetes post-operatively had higher Desulfovibrio species pre-operatively.Overall, RYGB produces greater and more predicted favourable changes in gut microbiota functional capacity than SG. An increase in Roseburia species was the only compositional change common to both types of surgery among those achieving diabetes remission. en
dc.format.medium Print en
dc.language eng en
dc.publisher FD-Communications Inc. en
dc.relation.ispartofseries Obesity Surgery en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission en
dc.type Journal Article en
dc.identifier.doi 10.1007/s11695-016-2399-2 en
pubs.issue 4 en
pubs.begin-page 917 en
pubs.volume 27 en
dc.rights.holder Copyright: Springer Verlag en
dc.identifier.pmid 27738970 en
pubs.end-page 925 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 542945 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Pharmacy en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Obstetrics and Gynaecology en
pubs.org-id Surgery Department en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1708-0428 en
pubs.record-created-at-source-date 2017-08-10 en
pubs.dimensions-id 27738970 en

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