Variation of human milk glucocorticoids over 24 hour period

Show simple item record Pundir, Shikha en Wall, Clare en Mitchell, Cameron en Thorstensen, Eric en Lai, CT en Geddes, DT en Cameron-Smith, David en 2017-08-15T02:55:30Z en 2017-03 en
dc.identifier.citation Journal of Mammary Gland Biology and Neoplasia 22(1):85-92 Mar 2017 en
dc.identifier.issn 1083-3021 en
dc.identifier.uri en
dc.description.abstract Human milk (HM) contains a complex array of hormones, including members of the glucocorticoid family. The predominant glucocorticoids, cortisol and cortisone may influence the growth and behaviour of the breastfed infant. However, little is understood of the factors regulating the levels of these hormones within HM. The aim of the study was to examine HM cortisol and cortisone concentration, measured in samples collected at each feed during a 24 hour period. Twenty three exclusively breastfeeding mothers collected milk, prior to and after each breastfeeding session over 24 hour period at 3.2(1.60) months. HM cortisol and cortisone levels were measured using high pressure liquid chromatography mass spectroscopy. Cortisone was the predominant glucocorticoid (3.40 ng/ml), and cortisol was detected in all samples (1.62 ng/ml). A positive correlation was found between cortisone and cortisol (r = 0.61, y = 1.93 ± 0.24, p < 0.0001). Cortisol and cortisone concentrations were significantly higher in feeds in the morning (2.97 ng/ml and 4.88 ng/ml), compared to afternoon (1.20 ng/ml and 3.54 ng/ml), evening (0.69 ng/ml and 2.13 ng/ml) and night (1.59 and 3.27 ng/ml). No difference was found between glucocorticoids level of the milk expressed for collection either before or immediately after the breastfeed, or between milk collected from the left or right breast. This study shows that HM glucocorticoid concentrations exhibit a 24 hour pattern, with highest peak levels in the early morning, reflecting the circadian pattern as previously reported in plasma. Thus, HM glucocorticoid concentrations are likely to reflect those in the maternal circulation. en
dc.format.medium Print-Electronic en
dc.language eng en
dc.publisher Springer Verlag en
dc.relation.ispartofseries Journal of Mammary Gland Biology and Neoplasia en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Variation of human milk glucocorticoids over 24 hour period en
dc.type Journal Article en
dc.identifier.doi 10.1007/s10911-017-9375-x en
pubs.issue 1 en
pubs.begin-page 85 en
pubs.volume 22 en
dc.rights.holder Copyright: Springer Verlag en
dc.identifier.pmid 28144768 en
pubs.end-page 92 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 611615 en Medical and Health Sciences en Medical Sciences en Nutrition en
dc.identifier.eissn 1573-7039 en
pubs.record-created-at-source-date 2017-08-15 en
pubs.dimensions-id 28144768 en

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