dc.contributor.author |
Nederveen, JP |
en |
dc.contributor.author |
Snijders, T |
en |
dc.contributor.author |
Joanisse, S |
en |
dc.contributor.author |
Wavell, CG |
en |
dc.contributor.author |
Mitchell, Cameron |
en |
dc.contributor.author |
Johnston, LM |
en |
dc.contributor.author |
Baker, SK |
en |
dc.contributor.author |
Phillips, SM |
en |
dc.contributor.author |
Parise, G |
en |
dc.date.accessioned |
2017-08-15T03:06:26Z |
en |
dc.date.issued |
2017-01 |
en |
dc.identifier.issn |
0363-6119 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/35102 |
en |
dc.description.abstract |
Skeletal muscle satellite cells (SC) play an important role in muscle adaptation. In untrained individuals, SC content and activation status have been observed to increase in response to a single bout of exercise. Muscle fiber characteristics change considerably when resistance exercise is performed chronically, but whether training status affects the activity of SC in response to a single bout of exercise remains unknown. We examined the changes in SC content and activation status following a single bout of resistance exercise, before and following a 16-wk progressive resistance training (RT) program in 14 young (25 ± 3 yr) men. Before and after RT, percutaneous biopsies from the vastus lateralis muscle were taken before a single bout of resistance exercise and after 24 and 72 h of postexercise recovery. Muscle fiber size, capillarization, and SC response were determined by immunohistochemistry. Following RT, there was a greater activation of SC after 24 h in response to a single bout of resistance exercise (Pre, 1.4 ± 0.3; 24 h, 3.1 ± 0.3 Pax7+/MyoD+ cells per 100 fibers) compared with before RT (Pre, 1.4 ± 0.3; 24 h, 2.2 ± 0.3 Pax7+/MyoD+ cells per 100 fibers, P < 0.05); no difference was observed 72 h postexercise. Following 16 wk of RT, MyoD mRNA expression increased from basal to 24 h after the single bout of exercise (P < 0.05); this change was not observed before training. Individual capillary-to-fiber ratio (C/Fi) increased in both type I (1.8 ± 0.3 to 2.0 ± 0.3 C/Fi, P < 0.05) and type II (1.7 ± 0.3 to 2.2 ± 0.3 C/Fi, P < 0.05) fibers in response to RT. After RT, enhanced activation of SC in response to resistance exercise is accompanied by increases in muscle fiber capillarization. |
en |
dc.format |
American Journal of Physiology - Regulatory Integrative and Comparative Physiology 312(1):R85-R92 Jan 2017 |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
American Physiological Society |
en |
dc.relation.ispartofseries |
American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Muscle, Skeletal |
en |
dc.subject |
Satellite Cells, Skeletal Muscle |
en |
dc.subject |
Humans |
en |
dc.subject |
Adaptation, Physiological |
en |
dc.subject |
Cell Differentiation |
en |
dc.subject |
Cell Proliferation |
en |
dc.subject |
Adult |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Resistance Training |
en |
dc.subject |
Physical Conditioning, Human |
en |
dc.title |
Altered muscle satellite cell activation following 16 wk of resistance training in young men |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1152/ajpregu.00221.2016 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
R85 |
en |
pubs.volume |
312 |
en |
dc.rights.holder |
Copyright: American Physiological Society |
en |
dc.identifier.pmid |
27834290 |
en |
pubs.end-page |
R92 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
607120 |
en |
dc.identifier.eissn |
1522-1490 |
en |
pubs.record-created-at-source-date |
2017-08-15 |
en |
pubs.dimensions-id |
27834290 |
en |