dc.contributor.author |
Scragg, Robert |
en |
dc.contributor.author |
Waayer, Debra |
en |
dc.contributor.author |
Stewart, Alistair |
en |
dc.contributor.author |
Lawes, CMM |
en |
dc.contributor.author |
Toop, L |
en |
dc.contributor.author |
Murphy, Judith |
en |
dc.contributor.author |
Khaw, K |
en |
dc.contributor.author |
Camargo, Carlos |
en |
dc.date.accessioned |
2017-08-16T00:49:13Z |
en |
dc.date.issued |
2016-11 |
en |
dc.identifier.citation |
The Journal of Steroid Biochemistry and Molecular Biology 164:318-325 Nov 2016 |
en |
dc.identifier.issn |
0960-0760 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/35125 |
en |
dc.description.abstract |
Observational studies have shown that low vitamin D status is associated with an increased risk of cardiovascular disease, acute respiratory infection, falls and non-vertebral fractures. We recruited 5110 Auckland adults, aged 50-84 years, into a randomized, double-blind, placebo-controlled trial to test whether vitamin D supplementation protects against these four major outcomes. The intervention is a monthly cholecalciferol dose of 100,000IU (2.5mg) for an estimated median 3.3 years (range 2.5-4.2) during 2011-2015. Participants were recruited primarily from family practices, plus community groups with a high proportion of Maori, Pacific, or South Asian individuals. The baseline evaluation included medical history, lifestyle, physical measurements (e.g. blood pressure, arterial waveform, lung function, muscle function), and a blood sample (stored at -80°C for later testing). Capsules are being mailed to home addresses with a questionnaire to collect data on non-hospitalized outcomes and to monitor adherence and potential adverse effects. Other data sources include New Zealand Ministry of Health data on mortality, hospitalization, cancer registrations and dispensed pharmaceuticals. A random sample of 438 participants returned for annual collection of blood samples to monitor adherence and safety (hypercalcemia), including repeat physical measurements at 12 months follow-up. The trial will allow testing of a priori hypotheses on several other endpoints including: weight, blood pressure, arterial waveform parameters, heart rate variability, lung function, muscle strength, gait and balance, mood, psoriasis, bone density, and chronic pain. |
en |
dc.format.medium |
Print-Electronic |
en |
dc.language |
eng |
en |
dc.publisher |
Pergamon Press Ltd. |
en |
dc.relation.ispartofseries |
The Journal of Steroid Biochemistry and Molecular Biology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Humans |
en |
dc.subject |
Respiratory Tract Infections |
en |
dc.subject |
Cardiovascular Diseases |
en |
dc.subject |
Cholecalciferol |
en |
dc.subject |
Respiratory Function Tests |
en |
dc.subject |
Gait |
en |
dc.subject |
Double-Blind Method |
en |
dc.subject |
Patient Compliance |
en |
dc.subject |
Affect |
en |
dc.subject |
Accidental Falls |
en |
dc.subject |
Blood Pressure |
en |
dc.subject |
Heart Rate |
en |
dc.subject |
Research Design |
en |
dc.subject |
Dietary Supplements |
en |
dc.subject |
Aged |
en |
dc.subject |
Aged, 80 and over |
en |
dc.subject |
Middle Aged |
en |
dc.subject |
Female |
en |
dc.subject |
Male |
en |
dc.subject |
Fractures, Bone |
en |
dc.subject |
Muscle Strength |
en |
dc.subject |
Postural Balance |
en |
dc.subject |
Surveys and Questionnaires |
en |
dc.title |
The Vitamin D Assessment (ViDA) Study: design of a randomized controlled trial of vitamin D supplementation for the prevention of cardiovascular disease, acute respiratory infection, falls and non-vertebral fractures |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.jsbmb.2015.09.010 |
en |
pubs.begin-page |
318 |
en |
pubs.volume |
164 |
en |
dc.rights.holder |
Copyright: Pergamon Press Ltd. |
en |
dc.identifier.pmid |
26365555 |
en |
pubs.end-page |
325 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
500578 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Faculty Administration FMHS |
en |
pubs.org-id |
FMHS Research Support |
en |
pubs.org-id |
Population Health |
en |
pubs.record-created-at-source-date |
2017-08-10 |
en |
pubs.dimensions-id |
26365555 |
en |