Increased cardiac work provides a link between systemic hypertension and heart failure

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dc.contributor.author Wilson, Alexander en
dc.contributor.author Wang, Yang en
dc.contributor.author Sands, Gregory en
dc.contributor.author Young, Alistair en
dc.contributor.author Nash, Martyn en
dc.contributor.author Le Grice, Ian en
dc.date.accessioned 2017-08-20T22:14:38Z en
dc.date.issued 2017-01 en
dc.identifier.citation Physiological Reports 5(1): e13104 Jan 2017 en
dc.identifier.issn 2051-817X en
dc.identifier.uri http://hdl.handle.net/2292/35214 en
dc.description.abstract The spontaneously hypertensive rat (SHR) is an established model of human hypertensive heart disease transitioning into heart failure. The study of the progression to heart failure in these animals has been limited by the lack of longitudinal data. We used MRI to quantify left ventricular mass, volume, and cardiac work in SHRs at age 3 to 21 month and compared these indices to data from Wistar-Kyoto (WKY) controls. SHR had lower ejection fraction compared with WKY at all ages, but there was no difference in cardiac output at any age. At 21 month the SHR had significantly elevated stroke work (51 ± 3 mL.mmHg SHR vs. 24 ± 2 mL.mmHg WKY; n = 8, 4; P < 0.001) and cardiac minute work (14.2 ± 1.2 L.mmHg/min SHR vs. 6.2 ± 0.8 L.mmHg/min WKY; n = 8, 4; P < 0.001) compared to control, in addition to significantly larger left ventricular mass to body mass ratio (3.61 ± 0.15 mg/g SHR vs. 2.11 ± 0.008 mg/g WKY; n = 8, 6; P < 0.001). SHRs showed impaired systolic function, but developed hypertrophy to compensate and successfully maintained cardiac output. However, this was associated with an increase in cardiac work at age 21 month, which has previously demonstrated fibrosis and cell death. The interplay between these factors may be the mechanism for progression to failure in this animal model. en
dc.format.medium Print en
dc.language eng en
dc.publisher Wiley en
dc.relation.ispartofseries Physiological Reports en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/2051-817X/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.title Increased cardiac work provides a link between systemic hypertension and heart failure en
dc.type Journal Article en
dc.identifier.doi 10.14814/phy2.13104 en
pubs.issue 1 en
pubs.volume 5 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 28082430 en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 606600 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Engineering en
pubs.org-id Engineering Science en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Anatomy and Medical Imaging en
pubs.org-id Physiology Division en
dc.identifier.eissn 2051-817X en
pubs.number e13104 en
pubs.record-created-at-source-date 2017-08-21 en
pubs.dimensions-id 28082430 en


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