Changes in In Vivo myocardial tissue properties due to heart failure

Wang, Yang; Young, Alistair; Cowan, Brett; Nash, Martyn

dc.contributor.author	Wang, Yang	en
dc.contributor.author	Young, Alistair	en
dc.contributor.author	Cowan, Brett	en
dc.contributor.author	Nash, Martyn	en
dc.coverage.spatial	London, U.K.	en
dc.date.accessioned	2017-08-21T03:52:24Z	en
dc.date.issued	2013	en
dc.identifier.citation	FIMH: International Conference on Functional Imaging and Modeling of the Heart. Springer Verlag. 7945: 216-223. 2013	en
dc.identifier.isbn	978-3-642-38898-9	en
dc.identifier.issn	0302-9743	en
dc.identifier.uri	http://hdl.handle.net/2292/35241	en
dc.description.abstract	A clinical image data driven mechanics analysis was used to quantify changes in tissue-specific passive and contractile material properties for groups of normal and HF patients. We have developed an automated mechanics modelling framework to firstly construct left ventricular (LV) mechanics models based on shape information derived from non-invasive dynamic magnetic resonance images, then to characterise passive tissue stiffness and maximum contractile stress by matching the simulated LV mechanics with data from the dynamic cardiac images. Preliminary statistical analysis revealed that patients with hypertrophy or non-ischemic heart failure exhibited increased passive myocardial stiffness compared to the normals. Elevated maximum contractile stress was also observed for hypertrophic patients. Tissue-specific parameter estimation analysis of this kind can potentially be applied in the clinical setting to provide a more specific disease measure to assist with stratification of HF patients. © 2013 Springer-Verlag.	en
dc.description.uri	http://fimh2013.cs.ucl.ac.uk/	en
dc.publisher	Springer Verlag	en
dc.relation.ispartof	FIMH 2013: 7th International Conference on Functional Imaging and Modeling of the Heart	en
dc.relation.ispartofseries	FIMH: International Conference on Functional Imaging and Modeling of the Heart	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Changes in In Vivo myocardial tissue properties due to heart failure	en
dc.type	Conference Item	en
dc.identifier.doi	10.1007/978-3-642-38899-6_26	en
pubs.begin-page	216	en
pubs.volume	7945	en
dc.rights.holder	Copyright: Springer Verlag	en
pubs.end-page	223	en
pubs.finish-date	2013-06-22	en
pubs.start-date	2013-06-20	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Proceedings	en
pubs.elements-id	404695	en
pubs.org-id	Bioengineering Institute	en
pubs.org-id	ABI Associates	en
pubs.org-id	Engineering	en
pubs.org-id	Engineering Science	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	Medical Sciences	en
pubs.org-id	Anatomy and Medical Imaging	en
pubs.record-created-at-source-date	2014-01-07	en