dc.contributor.author |
Han, June |
en |
dc.contributor.author |
Taberner, Andrew |
en |
dc.contributor.author |
Tran, Kenneth |
en |
dc.contributor.author |
Nickerson, David |
en |
dc.contributor.author |
Nash, Martyn |
en |
dc.contributor.author |
Nielsen, Poul |
en |
dc.contributor.author |
Crampin, EJ |
en |
dc.contributor.author |
Loiselle, Denis |
en |
dc.date.accessioned |
2017-08-21T04:30:07Z |
en |
dc.date.issued |
2012 |
en |
dc.identifier.citation |
Journal of Applied Physiology 113(7):988-995 2012 |
en |
dc.identifier.issn |
8750-7587 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/35245 |
en |
dc.description.abstract |
The concept of pressure-volume area (PVA) in whole heart studies is central to the phenome- nological description of cardiac energetics proposed by Suga and colleagues (Physiol Rev 70: 247–277, 1990). PVA consists of two components: an approxi- mately rectangular work loop (W) and an approximately triangular region of potential energy (U). In the case of isovolumic contractions, PVA consists entirely of U. The utility of Suga’s description of cardiac energetics is the observation that the oxygen consumption of the heart (V ̇ O2) is linearly dependent on PVA. By using isolated ventricular trabeculae, we found a basis on which to correlate the compo- nents of stress-length area (SLA; i.e., the 1-D equivalent of PVA) with specific regions of the stress-time integral (STI; i.e., the area under the force-time profile of a single twitch). In each case, proportionality obtains and is robust, independent of the type of twitch contraction (isometric or isotonic), and insensitive to changes of preload or afterload. We apply our results by examining retrospectively the interpretations reached in three independent studies published in the literature. |
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dc.publisher |
American Physiological Society |
en |
dc.relation.ispartofseries |
Journal of Applied Physiology |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.subject |
PVA force-time integral trabeculae enthalpy heat work |
en |
dc.title |
Relating components of pressure-volume area in Suga's formulation of cardiac energetics to components of the stress-time integral |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1152/japplphysiol.00438.2012 |
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pubs.issue |
7 |
en |
pubs.begin-page |
988 |
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pubs.volume |
113 |
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dc.rights.holder |
Copyright: American Physiological Society |
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dc.identifier.pmid |
22837173 |
en |
pubs.end-page |
995 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
358846 |
en |
pubs.org-id |
Bioengineering Institute |
en |
pubs.org-id |
ABI Associates |
en |
pubs.org-id |
Engineering |
en |
pubs.org-id |
Engineering Science |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
dc.identifier.eissn |
1522-1601 |
en |
pubs.record-created-at-source-date |
2012-07-26 |
en |
pubs.dimensions-id |
22837173 |
en |