Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial.

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dc.contributor.author Wickens, KL en
dc.contributor.author Barthow, CA en
dc.contributor.author Murphy, Rinki en
dc.contributor.author Abels, PR en
dc.contributor.author Maude, RM en
dc.contributor.author Stone, Peter en
dc.contributor.author Mitchell, Edwin en
dc.contributor.author Stanley, TV en
dc.contributor.author Purdie, GL en
dc.contributor.author Kang, JM en
dc.contributor.author Hood, FE en
dc.contributor.author Rowden, JL en
dc.contributor.author Barnes, PK en
dc.contributor.author Fitzharris, PF en
dc.contributor.author Crane, J en
dc.date.accessioned 2017-08-27T23:28:18Z en
dc.date.available 2017-01-24 en
dc.date.issued 2017-03-28 en
dc.identifier.citation British Journal of Nutrition, 117(6):804-813, 28 Mar 2017 en
dc.identifier.issn 0007-1145 en
dc.identifier.uri http://hdl.handle.net/2292/35380 en
dc.description.abstract The study aims to assess whether supplementation with the probiotic Lactobacillus rhamnosus HN001 (HN001) can reduce the prevalence of gestational diabetes mellitus (GDM). A double-blind, randomised, placebo-controlled parallel trial was conducted in New Zealand (NZ) (Wellington and Auckland). Pregnant women with a personal or partner history of atopic disease were randomised at 14-16 weeks' gestation to receive HN001 (6×109 colony-forming units) (n 212) or placebo (n 211) daily. GDM at 24-30 weeks was assessed using the definition of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) (fasting plasma glucose ≥5·1 mmol/l, or 1 h post 75 g glucose level at ≥10 mmol/l or at 2 h ≥8·5 mmol/l) and NZ definition (fasting plasma glucose ≥5·5 mmol/l or 2 h post 75 g glucose at ≥9 mmol/l). All analyses were intention-to-treat. A total of 184 (87 %) women took HN001 and 189 (90 %) women took placebo. There was a trend towards lower relative rates (RR) of GDM (IADPSG definition) in the HN001 group, 0·59 (95 % CI 0·32, 1·08) (P=0·08). HN001 was associated with lower rates of GDM in women aged ≥35 years (RR 0·31; 95 % CI 0·12, 0·81, P=0·009) and women with a history of GDM (RR 0·00; 95 % CI 0·00, 0·66, P=0·004). These rates did not differ significantly from those of women without these characteristics. Using the NZ definition, GDM prevalence was significantly lower in the HN001 group, 2·1 % (95 % CI 0·6, 5·2), v. 6·5 % (95 % CI 3·5, 10·9) in the placebo group (P=0·03). HN001 supplementation from 14 to 16 weeks' gestation may reduce GDM prevalence, particularly among older women and those with previous GDM. en
dc.description.uri https://www.ncbi.nlm.nih.gov/pubmed/28367765 en
dc.format.medium Print-Electronic en
dc.language English en
dc.publisher Cambridge University Press en
dc.relation.ispartofseries British Journal of Nutrition en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://sherpa.ac.uk/romeo/issn/0007-1145/ https://www.cambridge.org/core/services/open-access-policies en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Humans en
dc.subject Diabetes, Gestational en
dc.subject Blood Glucose en
dc.subject Prevalence en
dc.subject Double-Blind Method en
dc.subject Pregnancy en
dc.subject Probiotics en
dc.subject Adult en
dc.subject New Zealand en
dc.subject Female en
dc.subject Lactobacillus rhamnosus en
dc.title Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial. en
dc.type Journal Article en
dc.identifier.doi 10.1017/s0007114517000289 en
pubs.issue 6 en
pubs.begin-page 804 en
pubs.volume 117 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: The authors en
dc.identifier.pmid 28367765 en
pubs.author-url https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/early-pregnancy-probiotic-supplementation-with-lactobacillus-rhamnosus-hn001-may-reduce-the-prevalence-of-gestational-diabetes-mellitus-a-randomised-controlled-trial/D9D6EC718FA156F0929B5D902321F72E en
pubs.end-page 813 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Article en
pubs.elements-id 622706 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Obstetrics and Gynaecology en
pubs.org-id Paediatrics Child & Youth Hlth en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1475-2662 en
pubs.record-created-at-source-date 2017-08-28 en
pubs.online-publication-date 2017-04-03 en
pubs.dimensions-id 28367765 en

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