Targeting the cholinergic system to develop a novel therapy for Huntington's disease

D'Souza, GX; Waldvogel, Henry

dc.contributor.author	D'Souza, GX	en
dc.contributor.author	Waldvogel, Henry	en
dc.date.accessioned	2017-09-06T22:34:23Z	en
dc.date.issued	2016-12	en
dc.identifier.citation	Journal of Huntington's Disease 5(4):333-342 Dec 2016	en
dc.identifier.issn	1879-6397	en
dc.identifier.uri	http://hdl.handle.net/2292/35528	en
dc.description.abstract	In this review, we outline the role of the cholinergic system in Huntington's disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in post-mortem human brains and animal models of Huntington's disease. We postulate how the dysfunctional cholinergic system can be targeted to develop novel therapies for Huntington's disease, and discuss the beneficial effects of cholinergic therapies in pre-clinical and clinical studies.	en
dc.format.medium	Print	en
dc.language	eng	en
dc.publisher	IOS Press	en
dc.relation.ispartofseries	Journal of Huntington's Disease	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Targeting the cholinergic system to develop a novel therapy for Huntington's disease	en
dc.type	Journal Article	en
dc.identifier.doi	10.3233/JHD-160200	en
pubs.issue	4	en
pubs.begin-page	333	en
pubs.volume	5	en
dc.rights.holder	Copyright: IOS Press	en
dc.identifier.pmid	27983560	en
pubs.end-page	342	en
pubs.publication-status	Published	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Review	en
pubs.elements-id	603733	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	Medical Sciences	en
pubs.org-id	Anatomy and Medical Imaging	en
dc.identifier.eissn	1879-6400	en
pubs.record-created-at-source-date	2017-09-07	en
pubs.dimensions-id	27983560	en