dc.contributor.author |
Singh-Bains, Malvindar |
en |
dc.contributor.author |
Waldvogel, Henry |
en |
dc.contributor.author |
Faull, Richard |
en |
dc.date.accessioned |
2017-09-07T00:11:50Z |
en |
dc.date.issued |
2016-11 |
en |
dc.identifier.citation |
Brain Pathology 26(6):741-751 Nov 2016 |
en |
dc.identifier.issn |
1015-6305 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/35537 |
en |
dc.description.abstract |
Huntington's disease (HD) is characterized by pronounced pathology of the basal ganglia, with numerous studies documenting the pattern of striatal neurodegeneration in the human brain. However, a principle target of striatal outflow, the globus pallidus (GP), has received limited attention in comparison, despite being a core component of the basal ganglia. The external segment (GPe) is a major output of the dorsal striatum, connecting widely to other basal ganglia nuclei via the indirect motor pathway. The internal segment (GPi) is a final output station of both the direct and indirect motor pathways of the basal ganglia. The ventral pallidum (VP), in contrast, is a primary output of the limbic ventral striatum. Currently, there is a lack of consensus in the literature regarding the extent of GPe and GPi neurodegeneration in HD, with a conflict between pallidal neurons being preserved, and pallidal neurons being lost. In addition, no current evidence considers the fate of the VP in HD, despite it being a key structure involved in reward and motivation. Understanding the involvement of these structures in HD will help to determine their involvement in basal ganglia pathway dysfunction in the disease. A clear understanding of the impact of striatal projection loss on the main neurons that receive striatal input, the pallidal neurons, will aid in the understanding of disease pathogenesis. In addition, a clearer picture of pallidal involvement in HD may contribute to providing a morphological basis to the considerable variability in the types of motor, behavioral, and cognitive symptoms in HD. This review aims to highlight the importance of the globus pallidus, a critical component of the cortical-basal ganglia circuits, and its role in the pathogenesis of HD. This review also summarizes the current literature relating to human studies of the globus pallidus in HD. |
en |
dc.format.medium |
Print |
en |
dc.language |
eng |
en |
dc.publisher |
Wiley-Blackwell |
en |
dc.relation.ispartofseries |
Brain Pathology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
The role of the human globus pallidus in Huntington's disease |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/bpa.12429 |
en |
pubs.issue |
6 |
en |
pubs.begin-page |
741 |
en |
pubs.volume |
26 |
en |
dc.rights.holder |
Copyright: Wiley-Blackwell |
en |
dc.identifier.pmid |
27529459 |
en |
pubs.end-page |
751 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
540027 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Anatomy and Medical Imaging |
en |
dc.identifier.eissn |
1750-3639 |
en |
pubs.record-created-at-source-date |
2017-09-07 |
en |
pubs.dimensions-id |
27529459 |
en |