Chronic rhinosinusitis and the evolving understanding of microbial ecology in chronic inflammatory mucosal disease

Show simple item record Hoggard, M en Wagner, Brett en Jain, R en Taylor, Michael en Biswas, Kristi en Douglas, Richard en
dc.coverage.spatial United States en 2017-09-12T00:58:13Z en 2017-01-01 en
dc.identifier.citation Clinical Microbiology Reviews 30(1):321-348 01 Jan 2017 en
dc.identifier.issn 0893-8512 en
dc.identifier.uri en
dc.description.abstract Chronic rhinosinusitis (CRS) encompasses a heterogeneous group of debilitating chronic inflammatory sinonasal diseases. Despite considerable research, the etiology of CRS remains poorly understood, and debate on potential roles of microbial communities is unresolved. Modern culture-independent (molecular) techniques have vastly improved our understanding of the microbiology of the human body. Recent studies that better capture the full complexity of the microbial communities associated with CRS reintroduce the possible importance of the microbiota either as a direct driver of disease or as being potentially involved in its exacerbation. This review presents a comprehensive discussion of the current understanding of bacterial, fungal, and viral associations with CRS, with a specific focus on the transition to the new perspective offered in recent years by modern technology in microbiological research. Clinical implications of this new perspective, including the role of antimicrobials, are discussed in depth. While principally framed within the context of CRS, this discussion also provides an analogue for reframing our understanding of many similarly complex and poorly understood chronic inflammatory diseases for which roles of microbes have been suggested but specific mechanisms of disease remain unclear. Finally, further technological advancements on the horizon, and current pressing questions for CRS microbiological research, are considered. en
dc.language eng en
dc.publisher American Society for Microbiology en
dc.relation.ispartofseries Clinical Microbiology Reviews en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Chronic rhinosinusitis and the evolving understanding of microbial ecology in chronic inflammatory mucosal disease en
dc.type Journal Article en
dc.identifier.doi 10.1128/CMR.00060-16 en
pubs.issue 1 en
pubs.begin-page 321 en
pubs.volume 30 en
dc.description.version VoR - Version of Record en
dc.rights.holder Copyright: American Society for Microbiology en
dc.identifier.pmid 27903594 en
pubs.end-page 348 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 552324 en Medical and Health Sciences en School of Medicine en Surgery Department en Science en Biological Sciences en
dc.identifier.eissn 1098-6618 en
dc.identifier.pii 30/1/321 en
pubs.record-created-at-source-date 2017-09-12 en 2016-11-30 en
pubs.dimensions-id 27903594 en

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