dc.contributor.author |
Wagner, Brett |
en |
dc.contributor.author |
Waite, David |
en |
dc.contributor.author |
Hoggard, M |
en |
dc.contributor.author |
Douglas, Richard |
en |
dc.contributor.author |
Taylor, Michael |
en |
dc.contributor.author |
Biswas, Kristi |
en |
dc.coverage.spatial |
England |
en |
dc.date.accessioned |
2017-09-13T23:53:01Z |
en |
dc.date.available |
2016-11-22 |
en |
dc.date.issued |
2017-01 |
en |
dc.identifier.citation |
Environmental Microbiology 19(1):381-392 Jan 2017 |
en |
dc.identifier.issn |
1462-2912 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/35646 |
en |
dc.description.abstract |
Chronic rhinosinusitis (CRS) is a common, debilitating condition characterized by long-term inflammation of the nasal cavity and paranasal sinuses. The role of the sinonasal bacteria in CRS is unclear. We conducted a meta-analysis combining and reanalysing published bacterial 16S rRNA sequence data to explore differences in sinonasal bacterial community composition and predicted function between healthy and CRS affected subjects. The results identify the most abundant bacteria across all subjects as Staphylococcus, Propionibacterium, Corynebacterium, Streptococcus and an unclassified lineage of Actinobacteria. The meta-analysis results suggest that the bacterial community associated with CRS patients is dysbiotic and ecological networks fostering healthy communities are fragmented. Increased dispersion of bacterial communities, significantly lower bacterial diversity, and increased abundance of members of the genus Corynebacterium are associated with CRS. Increased relative abundance and diversity of other members belonging to the phylum Actinobacteria and members from the genera Propionibacterium differentiated healthy sinuses from those that were chronically inflamed. Removal of Burkholderia and Propionibacterium phylotypes from the healthy community dataset was correlated with a significant increase in network fragmentation. This meta-analysis highlights the potential importance of the genera Burkholderia and Propionibacterium as gatekeepers, whose presence may be important in maintaining a stable sinonasal bacterial community. |
en |
dc.language |
eng |
en |
dc.publisher |
Wiley |
en |
dc.relation.ispartofseries |
Environmental Microbiology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Bacterial community collapse: A meta-analysis of the sinonasal microbiota in chronic rhinosinusitis |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1111/1462-2920.13632 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
381 |
en |
pubs.volume |
19 |
en |
dc.rights.holder |
Copyright: Wiley |
en |
dc.identifier.pmid |
27902866 |
en |
pubs.end-page |
392 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
552325 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Surgery Department |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
dc.identifier.eissn |
1462-2920 |
en |
pubs.record-created-at-source-date |
2017-09-14 |
en |
pubs.online-publication-date |
2017-01-18 |
en |
pubs.dimensions-id |
27902866 |
en |